Depthwise-controlled scleral insertion of microneedles for drug delivery to the back of the eye

Seung Hyun Park, Dong Hyun Jo, Chang Sik Cho, Kang Ju Lee, Jin Hyoung Kim, Suho Ryu, Chulmin Joo, Jeong Hun Kim, Won Hyoung Ryu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

To treat retinal diseases, intravitreal injection is commonly performed to deliver therapeutic agents to the eye. However, intravitreal injection poses potential risks of ocular complications such as endophthalmitis, retinal detachment, and ocular hemorrhage. Thus, it is desired to develop a minimally invasive and therapeutically effective ocular drug delivery system without full penetration into the sclera. Here, we studied the possibility of precisely-controlled insertion of microneedles (MNs) into the sclera to different levels of depths and how different insertion depths could affect drug delivery into the sclera and to the back of the eye. A microneedle pen (MNP) was developed for depth-controlled scleral delivery by controlling insertion speeds, and it was confirmed that the insertion depths of MNs could be finely controlled by insertion speeds in ex vivo studies. Finite element modeling analyses were also conducted to understand how the depth-controlled insertion of MNs could significantly influence the diffusion distances of drug molecules. Finally, in vivo experiments demonstrated that this MNP system could be applied to the beagle eyes comparable to human ones for the scleral administration of therapeutic agents through the scleral tissues.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume133
DOIs
Publication statusPublished - 2018 Dec

Bibliographical note

Funding Information:
This work was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP [ NRF-2015M3A9E6028949 to Je.H. Kim], the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education [ 2017R1A6A3A04004741 to D.H. Jo], Mid-career Researcher Program through NRF grant funded by the MEST [ 2016R1A2B4010487 to W. Ryu], and the the NRF grant funded by the Korean Government (MSIT) [2015R1A5A1037668 to W. Ryu].

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Pharmaceutical Science

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