Abstract
To treat retinal diseases, intravitreal injection is commonly performed to deliver therapeutic agents to the eye. However, intravitreal injection poses potential risks of ocular complications such as endophthalmitis, retinal detachment, and ocular hemorrhage. Thus, it is desired to develop a minimally invasive and therapeutically effective ocular drug delivery system without full penetration into the sclera. Here, we studied the possibility of precisely-controlled insertion of microneedles (MNs) into the sclera to different levels of depths and how different insertion depths could affect drug delivery into the sclera and to the back of the eye. A microneedle pen (MNP) was developed for depth-controlled scleral delivery by controlling insertion speeds, and it was confirmed that the insertion depths of MNs could be finely controlled by insertion speeds in ex vivo studies. Finite element modeling analyses were also conducted to understand how the depth-controlled insertion of MNs could significantly influence the diffusion distances of drug molecules. Finally, in vivo experiments demonstrated that this MNP system could be applied to the beagle eyes comparable to human ones for the scleral administration of therapeutic agents through the scleral tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 31-41 |
| Number of pages | 11 |
| Journal | European Journal of Pharmaceutics and Biopharmaceutics |
| Volume | 133 |
| DOIs | |
| Publication status | Published - 2018 Dec 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biotechnology
- Pharmaceutical Science
Cite this
}
Depthwise-controlled scleral insertion of microneedles for drug delivery to the back of the eye. / Park, Seung Hyun; Jo, Dong Hyun; Cho, Chang Sik; Lee, Kang Ju; Kim, Jin Hyoung; Ryu, Suho; Joo, Chulmin; Kim, Jeong Hun; Ryu, WonHyoung.
In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 133, 01.12.2018, p. 31-41.Research output: Contribution to journal › Article
TY - JOUR
T1 - Depthwise-controlled scleral insertion of microneedles for drug delivery to the back of the eye
AU - Park, Seung Hyun
AU - Jo, Dong Hyun
AU - Cho, Chang Sik
AU - Lee, Kang Ju
AU - Kim, Jin Hyoung
AU - Ryu, Suho
AU - Joo, Chulmin
AU - Kim, Jeong Hun
AU - Ryu, WonHyoung
PY - 2018/12/1
Y1 - 2018/12/1
N2 - To treat retinal diseases, intravitreal injection is commonly performed to deliver therapeutic agents to the eye. However, intravitreal injection poses potential risks of ocular complications such as endophthalmitis, retinal detachment, and ocular hemorrhage. Thus, it is desired to develop a minimally invasive and therapeutically effective ocular drug delivery system without full penetration into the sclera. Here, we studied the possibility of precisely-controlled insertion of microneedles (MNs) into the sclera to different levels of depths and how different insertion depths could affect drug delivery into the sclera and to the back of the eye. A microneedle pen (MNP) was developed for depth-controlled scleral delivery by controlling insertion speeds, and it was confirmed that the insertion depths of MNs could be finely controlled by insertion speeds in ex vivo studies. Finite element modeling analyses were also conducted to understand how the depth-controlled insertion of MNs could significantly influence the diffusion distances of drug molecules. Finally, in vivo experiments demonstrated that this MNP system could be applied to the beagle eyes comparable to human ones for the scleral administration of therapeutic agents through the scleral tissues.
AB - To treat retinal diseases, intravitreal injection is commonly performed to deliver therapeutic agents to the eye. However, intravitreal injection poses potential risks of ocular complications such as endophthalmitis, retinal detachment, and ocular hemorrhage. Thus, it is desired to develop a minimally invasive and therapeutically effective ocular drug delivery system without full penetration into the sclera. Here, we studied the possibility of precisely-controlled insertion of microneedles (MNs) into the sclera to different levels of depths and how different insertion depths could affect drug delivery into the sclera and to the back of the eye. A microneedle pen (MNP) was developed for depth-controlled scleral delivery by controlling insertion speeds, and it was confirmed that the insertion depths of MNs could be finely controlled by insertion speeds in ex vivo studies. Finite element modeling analyses were also conducted to understand how the depth-controlled insertion of MNs could significantly influence the diffusion distances of drug molecules. Finally, in vivo experiments demonstrated that this MNP system could be applied to the beagle eyes comparable to human ones for the scleral administration of therapeutic agents through the scleral tissues.
UR - http://www.scopus.com/inward/record.url?scp=85054442851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054442851&partnerID=8YFLogxK
U2 - 10.1016/j.ejpb.2018.09.021
DO - 10.1016/j.ejpb.2018.09.021
M3 - Article
C2 - 30267835
AN - SCOPUS:85054442851
VL - 133
SP - 31
EP - 41
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
SN - 0939-6411
ER -