Depthwise-controlled scleral insertion of microneedles for drug delivery to the back of the eye

Seung Hyun Park, Dong Hyun Jo, Chang Sik Cho, Kang Ju Lee, Jin Hyoung Kim, Suho Ryu, Chulmin Joo, Jeong Hun Kim, WonHyoung Ryu

Research output: Contribution to journalArticle

Abstract

To treat retinal diseases, intravitreal injection is commonly performed to deliver therapeutic agents to the eye. However, intravitreal injection poses potential risks of ocular complications such as endophthalmitis, retinal detachment, and ocular hemorrhage. Thus, it is desired to develop a minimally invasive and therapeutically effective ocular drug delivery system without full penetration into the sclera. Here, we studied the possibility of precisely-controlled insertion of microneedles (MNs) into the sclera to different levels of depths and how different insertion depths could affect drug delivery into the sclera and to the back of the eye. A microneedle pen (MNP) was developed for depth-controlled scleral delivery by controlling insertion speeds, and it was confirmed that the insertion depths of MNs could be finely controlled by insertion speeds in ex vivo studies. Finite element modeling analyses were also conducted to understand how the depth-controlled insertion of MNs could significantly influence the diffusion distances of drug molecules. Finally, in vivo experiments demonstrated that this MNP system could be applied to the beagle eyes comparable to human ones for the scleral administration of therapeutic agents through the scleral tissues.

Original languageEnglish
Pages (from-to)31-41
Number of pages11
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume133
DOIs
Publication statusPublished - 2018 Dec 1

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Sclera
Intravitreal Injections
Pharmaceutical Preparations
Eye Hemorrhage
Retinal Hemorrhage
Retinal Diseases
Finite Element Analysis
Endophthalmitis
Retinal Detachment
Drug Delivery Systems
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Pharmaceutical Science

Cite this

Park, Seung Hyun ; Jo, Dong Hyun ; Cho, Chang Sik ; Lee, Kang Ju ; Kim, Jin Hyoung ; Ryu, Suho ; Joo, Chulmin ; Kim, Jeong Hun ; Ryu, WonHyoung. / Depthwise-controlled scleral insertion of microneedles for drug delivery to the back of the eye. In: European Journal of Pharmaceutics and Biopharmaceutics. 2018 ; Vol. 133. pp. 31-41.
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Depthwise-controlled scleral insertion of microneedles for drug delivery to the back of the eye. / Park, Seung Hyun; Jo, Dong Hyun; Cho, Chang Sik; Lee, Kang Ju; Kim, Jin Hyoung; Ryu, Suho; Joo, Chulmin; Kim, Jeong Hun; Ryu, WonHyoung.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 133, 01.12.2018, p. 31-41.

Research output: Contribution to journalArticle

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AU - Jo, Dong Hyun

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AU - Kim, Jin Hyoung

AU - Ryu, Suho

AU - Joo, Chulmin

AU - Kim, Jeong Hun

AU - Ryu, WonHyoung

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