Deracemization of amino acids by coupling transaminases of opposite stereoselectivity

Eul Soo Park, Jong Shik Shin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.

Original languageEnglish
Pages (from-to)3505-3509
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume356
Issue number17
DOIs
Publication statusPublished - 2014 Nov 24

Fingerprint

Stereoselectivity
Transaminases
Amino acids
Oxidoreductases
Keto Acids
Amino Acids
Enantiomers
Hydrogen peroxide
Hydrogen Peroxide
Acids
2-propylamine

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

Cite this

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abstract = "Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.",
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Deracemization of amino acids by coupling transaminases of opposite stereoselectivity. / Park, Eul Soo; Shin, Jong Shik.

In: Advanced Synthesis and Catalysis, Vol. 356, No. 17, 24.11.2014, p. 3505-3509.

Research output: Contribution to journalArticle

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