Deracemization of amino acids by coupling transaminases of opposite stereoselectivity

Eul Soo Park; Jong Shik Shin

doi:10.1002/adsc.201400185

Deracemization of amino acids by coupling transaminases of opposite stereoselectivity

Eul Soo Park, Jong Shik Shin

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.

Original language	English
Pages (from-to)	3505-3509
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	356
Issue number	17
DOIs	https://doi.org/10.1002/adsc.201400185
Publication status	Published - 2014 Nov 24

Bibliographical note

Publisher Copyright:
© 2014 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.

All Science Journal Classification (ASJC) codes

Catalysis
Organic Chemistry

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abstract = "Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.",

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N2 - Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.

AB - Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.

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Deracemization of amino acids by coupling transaminases of opposite stereoselectivity

Abstract

Bibliographical note

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