Abstract
Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.
| Original language | English |
|---|---|
| Pages (from-to) | 3505-3509 |
| Number of pages | 5 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 356 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 2014 Nov 24 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Organic Chemistry
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Park, E. S., & Shin, J. S. (2014). Deracemization of amino acids by coupling transaminases of opposite stereoselectivity. Advanced Synthesis and Catalysis, 356(17), 3505-3509. https://doi.org/10.1002/adsc.201400185