Deracemization of amino acids by coupling transaminases of opposite stereoselectivity

Eul Soo Park; Jong Shik Shin

doi:10.1002/adsc.201400185

Deracemization of amino acids by coupling transaminases of opposite stereoselectivity

Eul Soo Park, Jong Shik Shin

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.

Original language	English
Pages (from-to)	3505-3509
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	356
Issue number	17
DOIs	https://doi.org/10.1002/adsc.201400185
Publication status	Published - 2014 Nov 24

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All Science Journal Classification (ASJC) codes

Catalysis
Organic Chemistry

Cite this

Park, E. S., & Shin, J. S. (2014). Deracemization of amino acids by coupling transaminases of opposite stereoselectivity. Advanced Synthesis and Catalysis, 356(17), 3505-3509. https://doi.org/10.1002/adsc.201400185

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Access to Document

10.1002/adsc.201400185