Abstract
Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.
Original language | English |
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Pages (from-to) | 3505-3509 |
Number of pages | 5 |
Journal | Advanced Synthesis and Catalysis |
Volume | 356 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2014 Nov 24 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Organic Chemistry