Deracemization of amino acids by coupling transaminases of opposite stereoselectivity

Eul Soo Park, Jong Shik Shin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling a-and w-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.

Original languageEnglish
Pages (from-to)3505-3509
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume356
Issue number17
DOIs
Publication statusPublished - 2014 Nov 24

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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