Abstract
The Hippo pathway has drawn increasing interest in the past decade for its role in the regulation of cell growth, differentiation, organ size, and tissue homeostasis. Recent studies have expanded our knowledge of known upstream regulators of the Hippo pathway and have consistently demonstrated that the Hippo pathway is critical for translating cellular cues into transcriptional responses by receiving input from a wide range of upstream signals. Dramatic overgrowth phenotypes upon deregulation of the Hippo pathway have prompted investigation into its role in cancer. Here we provide an overview of the Hippo pathway, our current understanding of its role in tumorigenesis, and potential therapeutics targeting Hippo signaling.
| Original language | English |
|---|---|
| Pages (from-to) | 59-79 |
| Number of pages | 21 |
| Journal | Annual Review of Cancer Biology |
| Volume | 2 |
| DOIs | |
| Publication status | Published - 2018 |
Bibliographical note
Funding Information:We apologize for those primary works that are not cited due to the scope of this review and space constraints. This work was supported by grants to K.-L.G. from the National Institutes of Health (CA196878, DE15964, and GM51586). This work was additionally supported by grants to H.W.P. from the Korea Health Technology R&D Project (HI17C1560) through the Korea Health Industry Development Institute, funded by the Korean Ministry of Health & Welfare, and from the National Research Foundation of Korea (2017R1D1A1B03034797, 2017R1D1A1B03034797), funded by the Korean Ministry of Education and Ministry of Science, ICT (Information and Communications Technology), and Future Planning. K.C.L. was supported in part by the Graduate Training Program in Cellular and Molecular Pharmacology (T32 GM007752) from the University of California, San Diego (UCSD).
Funding Information:
We apologize for those primary works that are not cited due to the scope of this review and space constraints. This work was supported by grants to K.-L.G. from the National Institutes of Health (CA196878, DE15964, andGM51586).Thiswork was additionally supported by grants toH.W.P. from the Korea Health Technology R&D Project (HI17C1560) through the Korea Health Industry Development Institute, funded by the Korean Ministry of Health &Welfare, and from the National Research Foundation of Korea (2017R1D1A1B03034797, 2017R1D1A1B03034797), funded by the Korean Ministry of Education and Ministry of Science, ICT (Information and Communications Technology), and Future Planning. K.C.L. was supported in part by the Graduate Training Program in Cellular and Molecular Pharmacology (T32 GM007752) from the University of California, San Diego (UCSD).
Publisher Copyright:
© 2018 by Annual Reviews.
All Science Journal Classification (ASJC) codes
- Oncology
- Cell Biology
- Cancer Research
