Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1 (p. Glu192Lys)

Yun Ji Cha; Sae Bom Jeon; Jaewon Oh; Seung Tae Lee; Sangwoo Kim; Hyoeun Kim; Jungyoon Choi; Hyo Kyoung Choi; Dongju Won; Jong Rak Choi; Seok Jun Kim; Sahng Wook Park; Seok Min Kang; Seung Hyun Lee

doi:10.1016/j.scr.2022.102707

Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1 (p. Glu192Lys)

Yun Ji Cha, Sae Bom Jeon, Jaewon Oh, Seung Tae Lee, Sangwoo Kim, Hyoeun Kim, Jungyoon Choi, Hyo Kyoung Choi, Dongju Won, Jong Rak Choi, Seok Jun Kim, Sahng Wook Park, Seok Min Kang, Seung Hyun Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Dilated cardiomyopathy (DCM) is one of the leading causes of heart transplantation. The clinical feature of DCM is characterized by enlarged heart and impaired function of the left or both ventricles, while its etiology is varied. In this study, we generated YCMi005-A, a human-induced pluripotent stem cell (hiPSC) line from a patient with DCM carrying the missense mutation of p.Glu192Lys in the TPM1 genes. YCMi005-A, an established hiPSC, showed the normal karyotype (46, XX) and high expression of pluripotency markers. In addition, it was confirmed that YCMi005-A has the differentiation potential assessed by staining of three germ layer markers.

Original language	English
Article number	102707
Journal	Stem Cell Research
Volume	60
DOIs	https://doi.org/10.1016/j.scr.2022.102707
Publication status	Published - 2022 Apr

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT) (No. 2021R1I1A1A01042945, 2021R1I1A1A01060135, 2019R1C1C1002334). This study also was supported by Faculty research grant of Yonsei University College of Medicine (6-2021-0058), and a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). Human stem cell line, CMC-hiPSC-011 was provided by National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided from Catholic University.

Publisher Copyright:
© 2022 The Author(s)

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

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Cha, Y. J., Jeon, S. B., Oh, J., Lee, S. T., Kim, S., Kim, H., Choi, J., Choi, H. K., Won, D., Choi, J. R., Kim, S. J., Park, S. W., Kang, S. M., & Lee, S. H. (2022). Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1 (p. Glu192Lys). Stem Cell Research, 60, [102707]. https://doi.org/10.1016/j.scr.2022.102707

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title = "Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1 (p. Glu192Lys)",

abstract = "Dilated cardiomyopathy (DCM) is one of the leading causes of heart transplantation. The clinical feature of DCM is characterized by enlarged heart and impaired function of the left or both ventricles, while its etiology is varied. In this study, we generated YCMi005-A, a human-induced pluripotent stem cell (hiPSC) line from a patient with DCM carrying the missense mutation of p.Glu192Lys in the TPM1 genes. YCMi005-A, an established hiPSC, showed the normal karyotype (46, XX) and high expression of pluripotency markers. In addition, it was confirmed that YCMi005-A has the differentiation potential assessed by staining of three germ layer markers.",

author = "Cha, {Yun Ji} and Jeon, {Sae Bom} and Jaewon Oh and Lee, {Seung Tae} and Sangwoo Kim and Hyoeun Kim and Jungyoon Choi and Choi, {Hyo Kyoung} and Dongju Won and Choi, {Jong Rak} and Kim, {Seok Jun} and Park, {Sahng Wook} and Kang, {Seok Min} and Lee, {Seung Hyun}",

note = "Funding Information: This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT) (No. 2021R1I1A1A01042945, 2021R1I1A1A01060135, 2019R1C1C1002334). This study also was supported by Faculty research grant of Yonsei University College of Medicine (6-2021-0058), and a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). Human stem cell line, CMC-hiPSC-011 was provided by National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided from Catholic University. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = apr,

doi = "10.1016/j.scr.2022.102707",

language = "English",

volume = "60",

journal = "Stem Cell Research",

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Cha, YJ, Jeon, SB, Oh, J, Lee, ST, Kim, S, Kim, H, Choi, J, Choi, HK, Won, D, Choi, JR, Kim, SJ, Park, SW, Kang, SM & Lee, SH 2022, 'Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1 (p. Glu192Lys)', Stem Cell Research, vol. 60, 102707. https://doi.org/10.1016/j.scr.2022.102707

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AU - Cha, Yun Ji

AU - Jeon, Sae Bom

AU - Oh, Jaewon

AU - Lee, Seung Tae

AU - Kim, Sangwoo

AU - Kim, Hyoeun

AU - Choi, Jungyoon

AU - Choi, Hyo Kyoung

AU - Won, Dongju

AU - Choi, Jong Rak

AU - Kim, Seok Jun

AU - Park, Sahng Wook

AU - Kang, Seok Min

AU - Lee, Seung Hyun

N1 - Funding Information: This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT) (No. 2021R1I1A1A01042945, 2021R1I1A1A01060135, 2019R1C1C1002334). This study also was supported by Faculty research grant of Yonsei University College of Medicine (6-2021-0058), and a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). Human stem cell line, CMC-hiPSC-011 was provided by National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided from Catholic University. Publisher Copyright: © 2022 The Author(s)

PY - 2022/4

Y1 - 2022/4

N2 - Dilated cardiomyopathy (DCM) is one of the leading causes of heart transplantation. The clinical feature of DCM is characterized by enlarged heart and impaired function of the left or both ventricles, while its etiology is varied. In this study, we generated YCMi005-A, a human-induced pluripotent stem cell (hiPSC) line from a patient with DCM carrying the missense mutation of p.Glu192Lys in the TPM1 genes. YCMi005-A, an established hiPSC, showed the normal karyotype (46, XX) and high expression of pluripotency markers. In addition, it was confirmed that YCMi005-A has the differentiation potential assessed by staining of three germ layer markers.

AB - Dilated cardiomyopathy (DCM) is one of the leading causes of heart transplantation. The clinical feature of DCM is characterized by enlarged heart and impaired function of the left or both ventricles, while its etiology is varied. In this study, we generated YCMi005-A, a human-induced pluripotent stem cell (hiPSC) line from a patient with DCM carrying the missense mutation of p.Glu192Lys in the TPM1 genes. YCMi005-A, an established hiPSC, showed the normal karyotype (46, XX) and high expression of pluripotency markers. In addition, it was confirmed that YCMi005-A has the differentiation potential assessed by staining of three germ layer markers.

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Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1 (p. Glu192Lys)

Abstract

Bibliographical note

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