Dilated cardiomyopathy (DCM) is one of the leading causes of heart transplantation. The clinical feature of DCM is characterized by enlarged heart and impaired function of the left or both ventricles, while its etiology is varied. In this study, we generated YCMi005-A, a human-induced pluripotent stem cell (hiPSC) line from a patient with DCM carrying the missense mutation of p.Glu192Lys in the TPM1 genes. YCMi005-A, an established hiPSC, showed the normal karyotype (46, XX) and high expression of pluripotency markers. In addition, it was confirmed that YCMi005-A has the differentiation potential assessed by staining of three germ layer markers.
|Journal||Stem Cell Research|
|Publication status||Published - 2022 Apr|
Bibliographical noteFunding Information:
This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT) (No. 2021R1I1A1A01042945, 2021R1I1A1A01060135, 2019R1C1C1002334). This study also was supported by Faculty research grant of Yonsei University College of Medicine (6-2021-0058), and a grant from the Korea Food Research Institute funded by the Ministry of Science, ICT & Future Planning (E0210400). Human stem cell line, CMC-hiPSC-011 was provided by National Stem Cell Bank of Korea (Korea National Institute of Health), originally provided from Catholic University.
© 2022 The Author(s)
All Science Journal Classification (ASJC) codes
- Developmental Biology
- Cell Biology