New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.
Bibliographical noteFunding Information:
We acknowledge financial support from the Ministry of Health and Welfare (HMP-98-D-4-0027). Dr. K. T. No thanks the Basic Science Research Institute Program of the Ministry of Education (BSRI-96-3448) for research grants.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry