Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Cheol Kyu Han, Soon Kil Ahn, Nam Song Choi, Ryung Kee Hong, Seung Kee Moon, Hyoung Sik Chun, Sang Joon Lee, Jung Woo Kim, Chung Il Hong, Deukjoon Kim, Jeong Hyeok Yoon, Kyoung Tai No

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number1
DOIs
Publication statusPublished - 2000 Jan 3

Fingerprint

Molecular modeling
Endothelial cells
Molecular Structure
Esters
Endothelial Cells
Derivatives
methionine aminopeptidase 2
fumagillin
cinnamic acid
CKD 731
O-(chloroacetylcarbamoyl)fumagillol

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Han, Cheol Kyu ; Ahn, Soon Kil ; Choi, Nam Song ; Hong, Ryung Kee ; Moon, Seung Kee ; Chun, Hyoung Sik ; Lee, Sang Joon ; Kim, Jung Woo ; Hong, Chung Il ; Kim, Deukjoon ; Yoon, Jeong Hyeok ; No, Kyoung Tai. / Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 1. pp. 39-43.
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author = "Han, {Cheol Kyu} and Ahn, {Soon Kil} and Choi, {Nam Song} and Hong, {Ryung Kee} and Moon, {Seung Kee} and Chun, {Hyoung Sik} and Lee, {Sang Joon} and Kim, {Jung Woo} and Hong, {Chung Il} and Deukjoon Kim and Yoon, {Jeong Hyeok} and No, {Kyoung Tai}",
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Han, CK, Ahn, SK, Choi, NS, Hong, RK, Moon, SK, Chun, HS, Lee, SJ, Kim, JW, Hong, CI, Kim, D, Yoon, JH & No, KT 2000, 'Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2', Bioorganic and Medicinal Chemistry Letters, vol. 10, no. 1, pp. 39-43. https://doi.org/10.1016/S0960-894X(99)00577-6

Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. / Han, Cheol Kyu; Ahn, Soon Kil; Choi, Nam Song; Hong, Ryung Kee; Moon, Seung Kee; Chun, Hyoung Sik; Lee, Sang Joon; Kim, Jung Woo; Hong, Chung Il; Kim, Deukjoon; Yoon, Jeong Hyeok; No, Kyoung Tai.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 1, 03.01.2000, p. 39-43.

Research output: Contribution to journalArticle

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AU - Moon, Seung Kee

AU - Chun, Hyoung Sik

AU - Lee, Sang Joon

AU - Kim, Jung Woo

AU - Hong, Chung Il

AU - Kim, Deukjoon

AU - Yoon, Jeong Hyeok

AU - No, Kyoung Tai

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