Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Cheol Kyu Han, Soon Kil Ahn, Nam Song Choi, Ryung Kee Hong, Seung Kee Moon, Hyoung Sik Chun, Sang Joon Lee, Jung Woo Kim, Chung Il Hong, Deukjoon Kim, Jeong Hyeok Yoon, Kyoung Tai No

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Abstract

New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number1
DOIs
Publication statusPublished - 2000 Jan 3

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Han, C. K., Ahn, S. K., Choi, N. S., Hong, R. K., Moon, S. K., Chun, H. S., Lee, S. J., Kim, J. W., Hong, C. I., Kim, D., Yoon, J. H., & No, K. T. (2000). Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2. Bioorganic and Medicinal Chemistry Letters, 10(1), 39-43. https://doi.org/10.1016/S0960-894X(99)00577-6