Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Farhanullah; Su Yeon Kim; Eun Jeong Yoon; Eung Chil Choi; Sunghoon Kim; Taehee Kang; Farhana Samrin; Sadhna Puri; Jeewoo Lee

doi:10.1016/j.bmc.2006.06.062

Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Farhanullah, Su Yeon Kim, Eun Jeong Yoon, Eung Chil Choi, Sunghoon Kim, Taehee Kang, Farhana Samrin, Sadhna Puri, Jeewoo Lee

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.

Original language	English
Pages (from-to)	7154-7159
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	21
DOIs	https://doi.org/10.1016/j.bmc.2006.06.062
Publication status	Published - 2006 Nov 1

Bibliographical note

Funding Information:
This work was supported by a Grant (03-PJ2-PG4-BD02-0001) from the Ministry of Health and Welfare, R.O.K.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2006.06.062

Cite this

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title = "Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors",

abstract = "Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.",

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AU - Farhanullah,

AU - Kim, Su Yeon

AU - Yoon, Eun Jeong

AU - Choi, Eung Chil

AU - Kim, Sunghoon

AU - Kang, Taehee

AU - Samrin, Farhana

AU - Puri, Sadhna

AU - Lee, Jeewoo

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AB - Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.

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Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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