Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Farhanullah, Su Yeon Kim, Eun Jeong Yoon, Eung Chil Choi, Sunghoon Kim, Taehee Kang, Farhana Samrin, Sadhna Puri, Jeewoo Lee

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16 Citations (Scopus)

Abstract

Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.

Original languageEnglish
Pages (from-to)7154-7159
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number21
DOIs
Publication statusPublished - 2006 Nov 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Farhanullah, Kim, S. Y., Yoon, E. J., Choi, E. C., Kim, S., Kang, T., Samrin, F., Puri, S., & Lee, J. (2006). Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors. Bioorganic and Medicinal Chemistry, 14(21), 7154-7159. https://doi.org/10.1016/j.bmc.2006.06.062