Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing

Xinglu Huang, Fan Zhang, Yu Wang, Xiaolian Sun, Ki Young Choi, Dingbin Liu, Jin Sil Choi, Tae Hyun Shin, Jinwoo Cheon, Gang Niu, Xiaoyuan Chen

Research output: Contribution to journalArticle

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Abstract

Stem-cell-based therapies have attracted considerable interest in regenerative medicine and oncological research. However, a major limitation of systemic delivery of stem cells is the low homing efficiency to the target site. Here, we report a serendipitous finding that various iron-based magnetic nanoparticles (MNPs) actively augment chemokine receptor CXCR4 expression of bone-marrow-derived mesenchymal stem cells (MSCs). On the basis of this observation, we designed an iron-based nanocluster that can effectively label MSCs, improve cell homing efficiency, and track the fate of the cells in vivo. Using this nanocluster, the labeled MSCs were accurately monitored by magnetic resonance imaging and improved the homing to both traumatic brain injury and glioblastoma models as compared to unlabeled MSCs. Our findings provide a simple and safe method for imaging and targeted delivery of stem cells and extend the potential applications of iron-based MNPs in regenerative medicine and oncology.

Original languageEnglish
Pages (from-to)4403-4414
Number of pages12
JournalACS Nano
Volume8
Issue number5
DOIs
Publication statusPublished - 2014 May 27

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homing
stem cells
Nanoclusters
nanoclusters
Stem cells
Iron
iron
medicine
delivery
brain damage
Nanoparticles
Imaging techniques
nanoparticles
Oncology
bone marrow
Chemokine Receptors
Magnetic resonance
cells
magnetic resonance
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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Huang, X., Zhang, F., Wang, Y., Sun, X., Choi, K. Y., Liu, D., ... Chen, X. (2014). Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing. ACS Nano, 8(5), 4403-4414. https://doi.org/10.1021/nn4062726
Huang, Xinglu ; Zhang, Fan ; Wang, Yu ; Sun, Xiaolian ; Choi, Ki Young ; Liu, Dingbin ; Choi, Jin Sil ; Shin, Tae Hyun ; Cheon, Jinwoo ; Niu, Gang ; Chen, Xiaoyuan. / Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing. In: ACS Nano. 2014 ; Vol. 8, No. 5. pp. 4403-4414.
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Huang, X, Zhang, F, Wang, Y, Sun, X, Choi, KY, Liu, D, Choi, JS, Shin, TH, Cheon, J, Niu, G & Chen, X 2014, 'Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing', ACS Nano, vol. 8, no. 5, pp. 4403-4414. https://doi.org/10.1021/nn4062726

Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing. / Huang, Xinglu; Zhang, Fan; Wang, Yu; Sun, Xiaolian; Choi, Ki Young; Liu, Dingbin; Choi, Jin Sil; Shin, Tae Hyun; Cheon, Jinwoo; Niu, Gang; Chen, Xiaoyuan.

In: ACS Nano, Vol. 8, No. 5, 27.05.2014, p. 4403-4414.

Research output: Contribution to journalArticle

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T1 - Design considerations of iron-based nanoclusters for noninvasive tracking of mesenchymal stem cell homing

AU - Huang, Xinglu

AU - Zhang, Fan

AU - Wang, Yu

AU - Sun, Xiaolian

AU - Choi, Ki Young

AU - Liu, Dingbin

AU - Choi, Jin Sil

AU - Shin, Tae Hyun

AU - Cheon, Jinwoo

AU - Niu, Gang

AU - Chen, Xiaoyuan

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