Abstract
Novel ternary complexes formed from plasmid DNA, cationic peptides and anionic dendrimer photosensitizers were newly developed for the light-directed transfection. In this study, the atomic force microscopic (AFM) observation has revealed that the ternary complexes possessing optimal compositions had a spherical shape with the diameter of approximately 150nm and a narrow size distribution, and the in vitro biological studies have demonstrated that such ternary complexes showed the efficient light-induced transfection while showing little photocytotoxicity and cytotoxicity after a prolonged incubation. Thus, the ternary complexes are expected to be a promising non-viral vector for site-directed transfection in vivo.
Original language | English |
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Pages | 2187 |
Number of pages | 1 |
Publication status | Published - 2005 |
Event | 54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27 |
Other
Other | 54th SPSJ Annual Meeting 2005 |
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Country/Territory | Japan |
City | Yokohama |
Period | 05/5/25 → 05/5/27 |
All Science Journal Classification (ASJC) codes
- Engineering(all)