Design of nano-assemblies for the light-directed gene transfer [2]

Nobuhiro Nishiyama, Woo Dong Jang, Aya Akagi, Yuji Inoue, Yasuo Yanagi, Yasuhiro Tamaki, Kazunori Kataoka

Research output: Contribution to conferencePaperpeer-review


Novel ternary complexes formed from plasmid DNA, cationic peptides and anionic dendrimer photosensitizers were newly developed for the light-directed transfection. In this study, the atomic force microscopic (AFM) observation has revealed that the ternary complexes possessing optimal compositions had a spherical shape with the diameter of approximately 150nm and a narrow size distribution, and the in vitro biological studies have demonstrated that such ternary complexes showed the efficient light-induced transfection while showing little photocytotoxicity and cytotoxicity after a prolonged incubation. Thus, the ternary complexes are expected to be a promising non-viral vector for site-directed transfection in vivo.

Original languageEnglish
Number of pages1
Publication statusPublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27


Other54th SPSJ Annual Meeting 2005

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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