Design of pH-independent extended release matrix tablets of minocycline hydrochloride for the treatment of dementia

Kwang Ho Cha, Junsung Park, Wonkyung Cho, Dong Geon Gu, Kihyang Jeong, Sung Joo Hwang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The aim of this study was to develop a pH-independent extended release matrix tablet of minocycline HCl for the treatment of dementia. The matrix tablets were prepared by wet granulation technique using Eudragit L and S as release modifiers at different w/w ratios (1:0, 1:1 and 0:1) and PEO as a matrix former. In the case of the matrix tablet without any release modifiers, the drug release rate at pH 1.2 was much higher than that of pH 7.4. By adding the release modifier, the drug release rate at pH 7.4 increased close to that of pH 1.2 and the pH-independent release was obtained. In addition, it was shown that lubricants containing a divalent cation such as Mg stearate inhibited minocycline release in basic medium. Therefore, the incorporation of Eudragit L and S (1:1 ratio) as release modifiers and Na stearyl fumarate as a lubricant into PEO-based matrix tablets effectively produced pH-independent minocycline release profiles.

Original languageEnglish
Pages (from-to)1593-1598
Number of pages6
JournalArchives of pharmacal research
Volume32
Issue number11
DOIs
Publication statusPublished - 2009 Nov

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (No. R1720080250100102008).

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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