Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells

Byeong Ju Kwon, Xintong Wang, Mi Lan Kang, Jin You, Shin Jeong Lee, Won Shik Kim, Young Sup Yoon, Jong Chul Park, Hak Joon Sung

Research output: Contribution to journalReview article

Abstract

Stem cells are a promising cell source for regenerative medicine due to their differentiation and self-renewal capacities. In the field of regenerative medicine and tissue engineering, a variety of biomedical technologies have been tested to improve proangiogenic activities of stem cells. However, their therapeutic effect is found to be limited in the clinic because of cell loss, senescence, and insufficient therapeutic activities. To address this type of issue, advanced techniques for biomaterial synthesis and fabrication have been approached to mimic proangiogenic microenvironment and to direct proangiogenic activities. This review highlights the types of polymers and design strategies that have been studied to promote proangiogenic activities of stem cells. In particular, scaffolds, hydrogels, and surface topographies, as well as insight into their underlying mechanisms to improve proangiogenic activities are the focuses. The strategy to promote angiogenic activities of hMSCs by controlling substrate repellency is introduced, and the future direction is proposed.

Original languageEnglish
Article number1700340
JournalMacromolecular Bioscience
Volume18
Issue number2
DOIs
Publication statusPublished - 2018 Feb

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Stem cells
Cell culture
Regenerative Medicine
Stem Cells
Substrates
Biomedical Technology
Hydrogels
Cell Aging
Biocompatible Materials
Surface topography
Therapeutic Uses
Tissue Engineering
Tissue engineering
Biomaterials
Scaffolds
Polymers
Fabrication
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Kwon, B. J., Wang, X., Kang, M. L., You, J., Lee, S. J., Kim, W. S., ... Sung, H. J. (2018). Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells. Macromolecular Bioscience, 18(2), [1700340]. https://doi.org/10.1002/mabi.201700340
Kwon, Byeong Ju ; Wang, Xintong ; Kang, Mi Lan ; You, Jin ; Lee, Shin Jeong ; Kim, Won Shik ; Yoon, Young Sup ; Park, Jong Chul ; Sung, Hak Joon. / Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells. In: Macromolecular Bioscience. 2018 ; Vol. 18, No. 2.
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Design of Polymeric Culture Substrates to Promote Proangiogenic Potential of Stem Cells. / Kwon, Byeong Ju; Wang, Xintong; Kang, Mi Lan; You, Jin; Lee, Shin Jeong; Kim, Won Shik; Yoon, Young Sup; Park, Jong Chul; Sung, Hak Joon.

In: Macromolecular Bioscience, Vol. 18, No. 2, 1700340, 02.2018.

Research output: Contribution to journalReview article

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AU - Kwon, Byeong Ju

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AU - You, Jin

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AU - Kim, Won Shik

AU - Yoon, Young Sup

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