Design of surface-modified poly(d,l-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone

Sung Wook Choi, Jung Hyun Kim

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles, modified with both alendronate and polyethylene glycol (PEG), were prepared by dialysis method without additional surfactant to evaluate the potency of the bone-targeted drug delivery. Alendronate, a targeting moiety that has a strong affinity for bone, was conjugated to PLGA polymer via carbodiimide chemistry. Monomethoxy PEG(mPEG)-PLGA block copolymers with different molecular weights of mPEG (Mn 550, 750, and 2000) were synthesized and used for a hydrophilic layer on the surface of the nanoparticles to avoid reticuloendothelial system (RES). The surface-modified PLGA nanoparticles with various ratios of alendronate and mPEG densities on their surface were evaluated by adsorption study onto hydroxyapatite (HA). It was confirmed that alendronate-modified nanoparticles had a strong and specific adsorption to HA. The amount of nanoparticles absorbed onto HA tended to be smaller when the content of alendronate was decreased and the large block length of mPEG was found to reduce the potency of alendronate.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalJournal of Controlled Release
Volume122
Issue number1
DOIs
Publication statusPublished - 2007 Sep 11

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Alendronate
Nanoparticles
Bone and Bones
Durapatite
Pharmaceutical Preparations
Adsorption
Carbodiimides
Mononuclear Phagocyte System
Surface-Active Agents
dilactide
Dialysis
Polymers
Molecular Weight
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

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abstract = "Poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles, modified with both alendronate and polyethylene glycol (PEG), were prepared by dialysis method without additional surfactant to evaluate the potency of the bone-targeted drug delivery. Alendronate, a targeting moiety that has a strong affinity for bone, was conjugated to PLGA polymer via carbodiimide chemistry. Monomethoxy PEG(mPEG)-PLGA block copolymers with different molecular weights of mPEG (Mn 550, 750, and 2000) were synthesized and used for a hydrophilic layer on the surface of the nanoparticles to avoid reticuloendothelial system (RES). The surface-modified PLGA nanoparticles with various ratios of alendronate and mPEG densities on their surface were evaluated by adsorption study onto hydroxyapatite (HA). It was confirmed that alendronate-modified nanoparticles had a strong and specific adsorption to HA. The amount of nanoparticles absorbed onto HA tended to be smaller when the content of alendronate was decreased and the large block length of mPEG was found to reduce the potency of alendronate.",
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Design of surface-modified poly(d,l-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone. / Choi, Sung Wook; Kim, Jung Hyun.

In: Journal of Controlled Release, Vol. 122, No. 1, 11.09.2007, p. 24-30.

Research output: Contribution to journalArticle

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