Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers

Hwa Sil Kim, Yoonjee Kim, Munikumar Reddy Doddareddy, Seon Hee Seo, Hyewhon Rhim, Jinsung Tae, Ae Nim Pae, Hyunah Choo, Yong Seo Cho

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calcium channel blocking activity with IC 50 values of 0.93 and 0.96 μM, respectively.

Original languageEnglish
Pages (from-to)476-481
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number2
DOIs
Publication statusPublished - 2007 Jan 15

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T-Type Calcium Channels
Calcium Channel Blockers
Small Molecule Libraries
Derivatives
Molecules
1,3-dioxoisoindoline-5-carboxamide

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Kim, Hwa Sil ; Kim, Yoonjee ; Doddareddy, Munikumar Reddy ; Seo, Seon Hee ; Rhim, Hyewhon ; Tae, Jinsung ; Pae, Ae Nim ; Choo, Hyunah ; Cho, Yong Seo. / Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 2. pp. 476-481.
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Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers. / Kim, Hwa Sil; Kim, Yoonjee; Doddareddy, Munikumar Reddy; Seo, Seon Hee; Rhim, Hyewhon; Tae, Jinsung; Pae, Ae Nim; Choo, Hyunah; Cho, Yong Seo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 2, 15.01.2007, p. 476-481.

Research output: Contribution to journalArticle

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AU - Seo, Seon Hee

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