Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers

Hwa Sil Kim, Yoonjee Kim, Munikumar Reddy Doddareddy, Seon Hee Seo, Hyewhon Rhim, Jinsung Tae, Ae Nim Pae, Hyunah Choo, Yong Seo Cho

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A small molecule library of 1,3-dioxoisoindoline-5-carboxamides 4 was designed based on the pharmacophore model, synthesized and biologically evaluated as potential T-type calcium channel blockers. The most active compounds 4d and 4n show T-type calcium channel blocking activity with IC50 values of 0.93 and 0.96 μM, respectively.

Original languageEnglish
Pages (from-to)476-481
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number2
DOIs
Publication statusPublished - 2007 Jan 15

Bibliographical note

Funding Information:
This work was supported by Korea Institute of Science and Technology (2E18970).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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