Designer nanorings with functional cavities from self-assembling β-Sheet peptides

Il Soo Park, You Rim Yoon, Minseon Jung, Kimoon Kim, Seongbyeong Park, Seokmin Shin, Yong Beom Lim, Myongsoo Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

β-Barrel proteins that take the shape of a ring are common in many types of water-soluble enzymes and water-insoluble transmembrane pore-forming proteins. Since β-barrel proteins perform diverse functions in the cell, it would be a great step towards developing artificial proteins if we can control the polarity of artificial β-barrel proteins at will. Here, we describe a rational approach to construct β-barrel protein mimics from the self-assembly of peptide-based building blocks. With this approach, the direction of the self-assembly process toward the formation of water-soluble β-barrel nanorings or water-insoluble transmembrane β-barrel pores could be controlled by the simple but versatile molecular manipulation of supramolecular building blocks. This study not only delineates the basic driving force that underlies the folding of β-barrel proteins, but also lays the foundation for the facile fabrication of β-barrel protein mimics, which can be developed as nanoreactors, ion- and small-molecule-selective pores, and novel antibiotics.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalChemistry - An Asian Journal
Volume6
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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