Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis

C. Y. Ko; T. W. Lee; D. G. Woo; B. Y. Lee; H. S. Kim

Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis

C. Y. Ko, T. W. Lee, D. G. Woo, B. Y. Lee, H. S. Kim

Division of Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Many prevention and treatment have been developed to resolve the increasing problem of the osteoporotic fractures. Some researchers proposed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. However, there were few studies for detecting and tracking the effect of mechanical stimulation on osteoporotic bone. In the present study, the correlation between the improvement of morphological & mechanical characteristics and the effect of WBV were investigated and analyzed in OVX rats. The rats were randomly assigned to 5 groups: control, sham, WBV 17Hz, WBV 30Hz and WBV 45Hz. The WBV groups were exercised on a vibration platform (magnitude: 1mmp-p, frequency: 17Hz, 30Hz and 45Hz, 30minutes/day, 5days/week). The 4th lumbar vertebrae of rats were scanned by in-vivo micro computed tomography (micro-CT) at week 0 (just before WBV) and week 8 (after WBV). Structural parameters of the 4th lumbar vertebrae were investigated and analyzed. The quantitative decrement rates of trabecular bone on WBV groups with 30Hz and 45Hz were lower than those of control groups. For WBV group with 45Hz, the decrement rate of trabecular bone and its relative modulus were smaller than those of the control group. The results showed the beneficial effect of WBV on trabecular bones of OVX rats.

Original language	English
Title of host publication	Proceedings of the 5th International Conference on Engineering Computational Technology
Publication status	Published - 2006 Dec 1
Event	5th International Conference on Engineering Computational Technology, ECT 2006 - Las Palmas de Gran Canaria, Spain Duration: 2006 Sep 12 → 2006 Sep 15

Publication series

Name	Proceedings of the 5th International Conference on Engineering Computational Technology

Other

Other	5th International Conference on Engineering Computational Technology, ECT 2006
Country	Spain
City	Las Palmas de Gran Canaria
Period	06/9/12 → 06/9/15

All Science Journal Classification (ASJC) codes

Computer Science(all)

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Ko, C. Y., Lee, T. W., Woo, D. G., Lee, B. Y., & Kim, H. S. (2006). Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis. In Proceedings of the 5th International Conference on Engineering Computational Technology (Proceedings of the 5th International Conference on Engineering Computational Technology).

Ko, C. Y. ; Lee, T. W. ; Woo, D. G. ; Lee, B. Y. ; Kim, H. S. / Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis. Proceedings of the 5th International Conference on Engineering Computational Technology. 2006. (Proceedings of the 5th International Conference on Engineering Computational Technology).

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title = "Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis",

abstract = "Many prevention and treatment have been developed to resolve the increasing problem of the osteoporotic fractures. Some researchers proposed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. However, there were few studies for detecting and tracking the effect of mechanical stimulation on osteoporotic bone. In the present study, the correlation between the improvement of morphological & mechanical characteristics and the effect of WBV were investigated and analyzed in OVX rats. The rats were randomly assigned to 5 groups: control, sham, WBV 17Hz, WBV 30Hz and WBV 45Hz. The WBV groups were exercised on a vibration platform (magnitude: 1mmp-p, frequency: 17Hz, 30Hz and 45Hz, 30minutes/day, 5days/week). The 4th lumbar vertebrae of rats were scanned by in-vivo micro computed tomography (micro-CT) at week 0 (just before WBV) and week 8 (after WBV). Structural parameters of the 4th lumbar vertebrae were investigated and analyzed. The quantitative decrement rates of trabecular bone on WBV groups with 30Hz and 45Hz were lower than those of control groups. For WBV group with 45Hz, the decrement rate of trabecular bone and its relative modulus were smaller than those of the control group. The results showed the beneficial effect of WBV on trabecular bones of OVX rats.",

author = "Ko, {C. Y.} and Lee, {T. W.} and Woo, {D. G.} and Lee, {B. Y.} and Kim, {H. S.}",

year = "2006",

month = dec,

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language = "English",

isbn = "1905088094",

series = "Proceedings of the 5th International Conference on Engineering Computational Technology",

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Ko, CY, Lee, TW, Woo, DG, Lee, BY & Kim, HS 2006, Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis. in Proceedings of the 5th International Conference on Engineering Computational Technology. Proceedings of the 5th International Conference on Engineering Computational Technology, 5th International Conference on Engineering Computational Technology, ECT 2006, Las Palmas de Gran Canaria, Spain, 06/9/12.

Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis. / Ko, C. Y.; Lee, T. W.; Woo, D. G.; Lee, B. Y.; Kim, H. S.

Proceedings of the 5th International Conference on Engineering Computational Technology. 2006. (Proceedings of the 5th International Conference on Engineering Computational Technology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Lee, T. W.

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AU - Kim, H. S.

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N2 - Many prevention and treatment have been developed to resolve the increasing problem of the osteoporotic fractures. Some researchers proposed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. However, there were few studies for detecting and tracking the effect of mechanical stimulation on osteoporotic bone. In the present study, the correlation between the improvement of morphological & mechanical characteristics and the effect of WBV were investigated and analyzed in OVX rats. The rats were randomly assigned to 5 groups: control, sham, WBV 17Hz, WBV 30Hz and WBV 45Hz. The WBV groups were exercised on a vibration platform (magnitude: 1mmp-p, frequency: 17Hz, 30Hz and 45Hz, 30minutes/day, 5days/week). The 4th lumbar vertebrae of rats were scanned by in-vivo micro computed tomography (micro-CT) at week 0 (just before WBV) and week 8 (after WBV). Structural parameters of the 4th lumbar vertebrae were investigated and analyzed. The quantitative decrement rates of trabecular bone on WBV groups with 30Hz and 45Hz were lower than those of control groups. For WBV group with 45Hz, the decrement rate of trabecular bone and its relative modulus were smaller than those of the control group. The results showed the beneficial effect of WBV on trabecular bones of OVX rats.

AB - Many prevention and treatment have been developed to resolve the increasing problem of the osteoporotic fractures. Some researchers proposed positive effects of whole body vibration (WBV) on osteoporotic trabecular bones of animals. However, there were few studies for detecting and tracking the effect of mechanical stimulation on osteoporotic bone. In the present study, the correlation between the improvement of morphological & mechanical characteristics and the effect of WBV were investigated and analyzed in OVX rats. The rats were randomly assigned to 5 groups: control, sham, WBV 17Hz, WBV 30Hz and WBV 45Hz. The WBV groups were exercised on a vibration platform (magnitude: 1mmp-p, frequency: 17Hz, 30Hz and 45Hz, 30minutes/day, 5days/week). The 4th lumbar vertebrae of rats were scanned by in-vivo micro computed tomography (micro-CT) at week 0 (just before WBV) and week 8 (after WBV). Structural parameters of the 4th lumbar vertebrae were investigated and analyzed. The quantitative decrement rates of trabecular bone on WBV groups with 30Hz and 45Hz were lower than those of control groups. For WBV group with 45Hz, the decrement rate of trabecular bone and its relative modulus were smaller than those of the control group. The results showed the beneficial effect of WBV on trabecular bones of OVX rats.

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M3 - Conference contribution

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Ko CY, Lee TW, Woo DG, Lee BY, Kim HS. Detecting and tracking effect of mechanical stimulation on the osteoporotic bone of OVX rats using in-vivo micro-CT and micro finite element analysis. In Proceedings of the 5th International Conference on Engineering Computational Technology. 2006. (Proceedings of the 5th International Conference on Engineering Computational Technology).