Detection of airborne viruses using electro-aerodynamic deposition and a field-effect transistor

Kyu Tae Park, Dong Guk Cho, Ji Woon Park, Seunghun Hong, Jungho Hwang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a technique for the detection of aerosolized viruses. Conventional field-effect-transistor (FET)-based techniques use solution-based processes, thus require antibody binding to the detection region of the FET prior to the supply of the analyte. With the method described here, virus-antibody-bound particles are delivered to the FET during detection; therefore, neither a pre-treatment antibody binding step on the FET channel nor washing process for virus-antibody-binding are necessary. Our method is based on the concept that virus-antibody-bound particles are larger than the virus or antibody alone, and thus have larger charge numbers following aerosol charging. When these particles are charged by negative ions and electro-aerodynamically deposited on a substrate, there exists a location on the substrate where neither lone virus nor antibody particles land, and where only virus-antibody-bound particles are deposited. If this location coincides with the channel of the FET, the resulting variation in the current can be used to indicate the existence of a virus. By aerosolizing a mixed solution of the virus and the antibody, only the virus-antibody-bound particles were transported to the swCNT-FET, and the electric current in the swCNT-FET decreased to 30% of that measured with no deposited particles.

Original languageEnglish
Article number17462
JournalScientific reports
Volume5
DOIs
Publication statusPublished - 2015 Dec 8

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antibody
aerodynamics
virus
detection
effect
substrate
particle
aerosol
ion

All Science Journal Classification (ASJC) codes

  • General

Cite this

Park, Kyu Tae ; Cho, Dong Guk ; Park, Ji Woon ; Hong, Seunghun ; Hwang, Jungho. / Detection of airborne viruses using electro-aerodynamic deposition and a field-effect transistor. In: Scientific reports. 2015 ; Vol. 5.
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Detection of airborne viruses using electro-aerodynamic deposition and a field-effect transistor. / Park, Kyu Tae; Cho, Dong Guk; Park, Ji Woon; Hong, Seunghun; Hwang, Jungho.

In: Scientific reports, Vol. 5, 17462, 08.12.2015.

Research output: Contribution to journalArticle

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