Detection of Amphipathic Viral Peptide on Screen-Printed Electrodes by Liposome Rupture Impact Voltammetry

Muhammad Zafir Mohamad Nasir; Joshua A. Jackman; Nam Joon Cho; Adriano Ambrosi; Martin Pumera

doi:10.1021/acs.analchem.7b03305

Detection of Amphipathic Viral Peptide on Screen-Printed Electrodes by Liposome Rupture Impact Voltammetry

Muhammad Zafir Mohamad Nasir, Joshua A. Jackman, Nam Joon Cho, Adriano Ambrosi, Martin Pumera

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Detection of infectious viruses and disease biomarkers is of utmost importance in clinical screening for effective identification and treatment of diseases. We demonstrate here the use of liposome rupture impact voltammetry for the qualitative detection of model amphipathic viral peptide on a screen-printed electrode. This novel, proof-of-concept method was proposed for the quick and reliable detection of viruses by nonfaradaic liposome rupture impact voltammetry with the aid of 1,2-dioleoyl-sn-glycero-3-phosphocholine liposomes. This provides an avenue for the development of future on-site, point-of-care detection devices for medical and biological applications.

Original language	English
Pages (from-to)	11753-11757
Number of pages	5
Journal	Analytical Chemistry
Volume	89
Issue number	21
DOIs	https://doi.org/10.1021/acs.analchem.7b03305
Publication status	Published - 2017 Nov 7

Bibliographical note

Funding Information:
M.P. acknowledges support from Tier 1 (99/13) from Singapore Ministry of Education. We thank J.A.J and N.-J. C. for providing the DOPC liposomes and AH peptide for the project.

All Science Journal Classification (ASJC) codes

Analytical Chemistry

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10.1021/acs.analchem.7b03305

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title = "Detection of Amphipathic Viral Peptide on Screen-Printed Electrodes by Liposome Rupture Impact Voltammetry",

abstract = "Detection of infectious viruses and disease biomarkers is of utmost importance in clinical screening for effective identification and treatment of diseases. We demonstrate here the use of liposome rupture impact voltammetry for the qualitative detection of model amphipathic viral peptide on a screen-printed electrode. This novel, proof-of-concept method was proposed for the quick and reliable detection of viruses by nonfaradaic liposome rupture impact voltammetry with the aid of 1,2-dioleoyl-sn-glycero-3-phosphocholine liposomes. This provides an avenue for the development of future on-site, point-of-care detection devices for medical and biological applications.",

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note = "Funding Information: M.P. acknowledges support from Tier 1 (99/13) from Singapore Ministry of Education. We thank J.A.J and N.-J. C. for providing the DOPC liposomes and AH peptide for the project.",

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AU - Ambrosi, Adriano

AU - Pumera, Martin

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