Detection of Coxiella burnetii using silicon microring resonator in patient blood plasma

Bonhan Koo, Choong Eun Jin, Moonsuk Bae, Yoon Ok Jang, Ji Yeun Kim, Sung Han Kim, Yong Shin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Blood plasma from patients is a powerful resource for diagnosing infectious disease due to it having many genetic materials as well as being relatively easy to obtain. Thus, various biosensors have been investigated for diagnosing diseases in blood plasma. However, there are no optimized and validated sensors for clinical use due to the low sensitivity, complexity, and difficulties of removing the inhibitors from plasma samples. In this study, we described a silicon microring resonator sensor used to detect Coxiella burnetii from the blood plasma of Q-fever patients in a label-free, real-time manner. Q-fever is an infectious disease caused by Coxiella burnetii via direct contact or inhalation aerosols. We validated this biosensor in the blood plasma of 35 clinical samples (including 16 Q fever samples infected with Coxiella burnetii and 19 samples infected with other febrile diseases. The biosensors are capable of rapid (10 min), highly sensitive (87.5%), and specific (89.5%) detection in plasma samples compared to the use of the conventional method.

Original languageEnglish
Article number427
JournalMicromachines
Volume10
Issue number7
DOIs
Publication statusPublished - 2019 Jul 1

Bibliographical note

Funding Information:
Funding: This study was funded by a grant from the Korea Health Technology R & D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea [HI16C-0272–010016].

Publisher Copyright:
© 2019 by the authors.

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Detection of Coxiella burnetii using silicon microring resonator in patient blood plasma'. Together they form a unique fingerprint.

Cite this