Detection of DNA hybridization on chemically modified graphene platforms

Marcella Giovanni, Alessandra Bonanni, Martin Pumera

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The increasing demand for simple, low-cost, rapid, sensitive and label-free methods for the detection of DNA sequences and the presence of single nucleotide polymorphisms (SNPs) has become an important issue in biomedical research. In this work, we studied the performances of several chemically modified graphene nanomaterials as sensing platforms by using the electrochemical impedance spectroscopy technique for the detection. We employed a hairpin DNA as a highly selective probe for the detection of SNP correlated to Alzheimer's disease. We believe that our findings may present a foundation for further research and development in graphene-based impedimetric biosensing.

Original languageEnglish
Pages (from-to)580-583
Number of pages4
JournalAnalyst
Volume137
Issue number3
DOIs
Publication statusPublished - 2012 Feb 7

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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