Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics

Juwon Kim, Tae Sung Park, Jaewoo Song, Kyung A. Lee, Duk Jin Hong, Yoo Hong Min, June Won Cheong, Jong Rak Choi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalCancer genetics and cytogenetics
Volume194
Issue number2
DOIs
Publication statusPublished - 2009 Oct 15

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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