Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics

Juwon Kim, Tae Sung Park, Jaewoo Song, Kyunga Lee, Duk Jin Hong, Yoo Hong Min, June Won Cheong, Jong Rak Choi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume194
Issue number2
DOIs
Publication statusPublished - 2009 Oct 15

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Acute Myeloid Leukemia
Chromosome Aberrations
Leukemia
DNA
RNA-Binding Motifs

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Kim, Juwon ; Park, Tae Sung ; Song, Jaewoo ; Lee, Kyunga ; Hong, Duk Jin ; Min, Yoo Hong ; Cheong, June Won ; Choi, Jong Rak. / Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics. In: Cancer Genetics and Cytogenetics. 2009 ; Vol. 194, No. 2. pp. 111-118.
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abstract = "Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.",
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Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics. / Kim, Juwon; Park, Tae Sung; Song, Jaewoo; Lee, Kyunga; Hong, Duk Jin; Min, Yoo Hong; Cheong, June Won; Choi, Jong Rak.

In: Cancer Genetics and Cytogenetics, Vol. 194, No. 2, 15.10.2009, p. 111-118.

Research output: Contribution to journalArticle

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