Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter

Seung Il Yoon, Mi Hwa Lim, Se Chul Park, Jeon Soo Shin, Yone Jun Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Detection of Neisseria meningitidis, that is one of the most common causes of bacterial meningitis, is being reported, using a micromachined microcalorimeter with a split-flow microchannel structure. The split-flow microchannel scheme constantly keeps the output of the microcalorimeter near zero level when there is no biochemical reaction, which eliminates the need of an active element such as a heater. Thermal components for the microcalorimeter have been fabricated on a high thermal resistivity layer to improve the sensitivity of the device. Using the fabricated sensor, a biological reaction between Neisseria meningitidis group B (NMGB) and a specific monoclonal antibody to its capsular polysaccharide was detected. In order to verify the reliability of the measurement, exactly same number of NMGB was reacted with HmenB3, and optical density was measured by ELISA.

Original languageEnglish
Title of host publicationProceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007
Pages509-512
Number of pages4
Publication statusPublished - 2007
Event20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007 - Kobe, Japan
Duration: 2007 Jan 212007 Jan 25

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007
CountryJapan
CityKobe
Period07/1/2107/1/25

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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