Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter

Seung Il Yoon, Mi Hwa Lim, Se Chul Park, Jeon Soo Shin, Yone Jun Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Detection of Neisseria meningitidis, that is one of the most common causes of bacterial meningitis, is being reported, using a micromachined microcalorimeter with a split-flow microchannel structure. The split-flow microchannel scheme constantly keeps the output of the microcalorimeter near zero level when there is no biochemical reaction, which eliminates the need of an active element such as a heater. Thermal components for the microcalorimeter have been fabricated on a high thermal resistivity layer to improve the sensitivity of the device. Using the fabricated sensor, a biological reaction between Neisseria meningitidis group B (NMGB) and a specific monoclonal antibody to its capsular polysaccharide was detected. In order to verify the reliability of the measurement, exactly same number of NMGB was reacted with HmenB3, and optical density was measured by ELISA.

Original languageEnglish
Title of host publicationProceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007
Pages509-512
Number of pages4
Publication statusPublished - 2007 Dec 1
Event20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007 - Kobe, Japan
Duration: 2007 Jan 212007 Jan 25

Other

Other20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007
CountryJapan
CityKobe
Period07/1/2107/1/25

Fingerprint

Microchannels
calorimeters
microchannels
Density (optical)
Monoclonal antibodies
meningitis
Polysaccharides
Thermal conductivity
polysaccharides
optical density
Monoclonal Antibodies
antibodies
heaters
Sensors
electrical resistivity
causes
output
sensitivity
sensors
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Yoon, S. I., Lim, M. H., Park, S. C., Shin, J. S., & Kim, Y. J. (2007). Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. In Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007 (pp. 509-512). [4433116]
Yoon, Seung Il ; Lim, Mi Hwa ; Park, Se Chul ; Shin, Jeon Soo ; Kim, Yone Jun. / Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. pp. 509-512
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Yoon, SI, Lim, MH, Park, SC, Shin, JS & Kim, YJ 2007, Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. in Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007., 4433116, pp. 509-512, 20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007, Kobe, Japan, 07/1/21.

Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. / Yoon, Seung Il; Lim, Mi Hwa; Park, Se Chul; Shin, Jeon Soo; Kim, Yone Jun.

Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. p. 509-512 4433116.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Yoon SI, Lim MH, Park SC, Shin JS, Kim YJ. Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. In Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. p. 509-512. 4433116