Abstract
To find out if polymerase chain reaction could be used as a diagnostic tool for detecting neurosyphilis, we have applied the PCR for the detection of Treponema pallidum DNA in the cerebrospinal fluid (CSF) of syphilis patients. The results of the PCR of the CSF in 26 patients with at various stages of illness were compared with the results of other conventional tests used in the WHO criteria. T. pallidum was detected in the CSF of patients at all stages of syphilis, which indicates that they invade the central nervous system from the early stages of infection. However, the presence of T. pallidum in the CSF was not correlated with the results of other tests used in the WHO criteria, and its significance in the diagnosis of neurosyphilis should further be evaluated.
| Original language | English |
|---|---|
| Pages (from-to) | 190-197 |
| Number of pages | 8 |
| Journal | Yonsei Medical Journal |
| Volume | 35 |
| Issue number | 2 |
| Publication status | Published - 1994 Jun 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
}
Detection of Treponema pallidum by polymerase chain reaction in the cerebrospinal fluid of syphilis patients. / Chung, K. Y.; Lee, M. G.; Lee, J. B.
In: Yonsei Medical Journal, Vol. 35, No. 2, 01.06.1994, p. 190-197.Research output: Contribution to journal › Article
TY - JOUR
T1 - Detection of Treponema pallidum by polymerase chain reaction in the cerebrospinal fluid of syphilis patients.
AU - Chung, K. Y.
AU - Lee, M. G.
AU - Lee, J. B.
PY - 1994/6/1
Y1 - 1994/6/1
N2 - To find out if polymerase chain reaction could be used as a diagnostic tool for detecting neurosyphilis, we have applied the PCR for the detection of Treponema pallidum DNA in the cerebrospinal fluid (CSF) of syphilis patients. The results of the PCR of the CSF in 26 patients with at various stages of illness were compared with the results of other conventional tests used in the WHO criteria. T. pallidum was detected in the CSF of patients at all stages of syphilis, which indicates that they invade the central nervous system from the early stages of infection. However, the presence of T. pallidum in the CSF was not correlated with the results of other tests used in the WHO criteria, and its significance in the diagnosis of neurosyphilis should further be evaluated.
AB - To find out if polymerase chain reaction could be used as a diagnostic tool for detecting neurosyphilis, we have applied the PCR for the detection of Treponema pallidum DNA in the cerebrospinal fluid (CSF) of syphilis patients. The results of the PCR of the CSF in 26 patients with at various stages of illness were compared with the results of other conventional tests used in the WHO criteria. T. pallidum was detected in the CSF of patients at all stages of syphilis, which indicates that they invade the central nervous system from the early stages of infection. However, the presence of T. pallidum in the CSF was not correlated with the results of other tests used in the WHO criteria, and its significance in the diagnosis of neurosyphilis should further be evaluated.
UR - http://www.scopus.com/inward/record.url?scp=0028454394&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028454394&partnerID=8YFLogxK
M3 - Article
VL - 35
SP - 190
EP - 197
JO - Yonsei Medical Journal
JF - Yonsei Medical Journal
SN - 0513-5796
IS - 2
ER -