Determination of optimal acquisition time of [ 18 F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects

Jae Yong Choi, Minkyung Lee, Tae Joo Jeon, Soo Hee Choi, Ye Ji Choi, Yu Kyung Lee, Jae-Jin Kim, Young Hoon Ryu

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Abstract

The purpose of this research is to find optimal acquisition time point of [ 18 F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT 1A ) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT 1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90min after injection and remained stable at 120min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90min p.i. is a better single time point for the analysis rather than previous time points for assessing [ 18 F]FCWAY binding to 5-HT 1A receptors.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalApplied Radiation and Isotopes
Volume89
DOIs
Publication statusPublished - 2014 Jan 1

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All Science Journal Classification (ASJC) codes

  • Radiation

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