Determination of optimal acquisition time of [18F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects

Jae Yong Choi; Minkyung Lee; Tae Joo Jeon; Soo Hee Choi; Ye Ji Choi; Yu Kyung Lee; Jae Jin Kim; Young Hoon Ryu

doi:10.1016/j.apradiso.2014.02.014

Determination of optimal acquisition time of [¹⁸F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects

Jae Yong Choi, Minkyung Lee, Tae Joo Jeon, Soo Hee Choi, Ye Ji Choi, Yu Kyung Lee, Jae Jin Kim, Young Hoon Ryu

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The purpose of this research is to find optimal acquisition time point of [¹⁸F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT_1A) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT_1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90min after injection and remained stable at 120min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90min p.i. is a better single time point for the analysis rather than previous time points for assessing [¹⁸F]FCWAY binding to 5-HT_1A receptors.

Original language	English
Pages (from-to)	141-145
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	89
DOIs	https://doi.org/10.1016/j.apradiso.2014.02.014
Publication status	Published - 2014 Jul

Bibliographical note

Funding Information:
This research was supported by Nuclear R&D Program through the National Research Foundation of Korea (Grant no. 2013M2A2A7029685 ).

All Science Journal Classification (ASJC) codes

Radiation

Access to Document

10.1016/j.apradiso.2014.02.014

Cite this

@article{ff4c5bd2656c4ee68d1290fd57c28c3a,

title = "Determination of optimal acquisition time of [18F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects",

abstract = "The purpose of this research is to find optimal acquisition time point of [18F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT1A) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90min after injection and remained stable at 120min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90min p.i. is a better single time point for the analysis rather than previous time points for assessing [18F]FCWAY binding to 5-HT1A receptors.",

author = "{Yong Choi}, Jae and Minkyung Lee and Jeon, {Tae Joo} and Choi, {Soo Hee} and Choi, {Ye Ji} and Lee, {Yu Kyung} and Kim, {Jae Jin} and Ryu, {Young Hoon}",

note = "Funding Information: This research was supported by Nuclear R&D Program through the National Research Foundation of Korea (Grant no. 2013M2A2A7029685 ).",

year = "2014",

month = jul,

doi = "10.1016/j.apradiso.2014.02.014",

language = "English",

volume = "89",

pages = "141--145",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

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T1 - Determination of optimal acquisition time of [18F]FCWAY PET for imaging serotonin 1A receptors in the healthy male subjects

AU - Yong Choi, Jae

AU - Lee, Minkyung

AU - Jeon, Tae Joo

AU - Choi, Soo Hee

AU - Choi, Ye Ji

AU - Lee, Yu Kyung

AU - Kim, Jae Jin

AU - Ryu, Young Hoon

N1 - Funding Information: This research was supported by Nuclear R&D Program through the National Research Foundation of Korea (Grant no. 2013M2A2A7029685 ).

PY - 2014/7

Y1 - 2014/7

N2 - The purpose of this research is to find optimal acquisition time point of [18F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT1A) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90min after injection and remained stable at 120min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90min p.i. is a better single time point for the analysis rather than previous time points for assessing [18F]FCWAY binding to 5-HT1A receptors.

AB - The purpose of this research is to find optimal acquisition time point of [18F]FCWAY PET for the assessment of serotonin 1A receptor (5-HT1A) density. To achieve this goal, we examined the specific-to-nonspecific ratios in various brain regions. The cerebellum has very few 5-HT1A receptors in the brain, so we set this region as the reference tissue. As a result, specific-to-nonspecific binding ratios in the frontal, temporal cortex and the hippocampus were steadily increased at 90min after injection and remained stable at 120min. In addition, the binding ratio of the late time was significantly higher than that of the previous time points. From these results, we recommend that 90min p.i. is a better single time point for the analysis rather than previous time points for assessing [18F]FCWAY binding to 5-HT1A receptors.

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