Determination of the triplet state energies of a series of conjugated porphyrin oligomers

Marina K. Kuimova, Markus Hoffmann, Mikael U. Winters, Mattias Eng, Milan Balaz, Ian P. Clark, Hazel A. Collins, Susan M. Tavender, Craig J. Wilson, Bo Albinsson, Harry L. Anderson, Anthony W. Parker, David Phillips

Research output: Contribution to journalArticle

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Abstract

We report a systematic study of the photophysical parameters relevant to photodynamic therapy (PDT) by a new type of sensitizers, conjugated porphyrin oligomers. Due to the strong nonlinear properties of oligomers containing 2, 4 and 8 porphyrin units, these molecules are attractive candidates for PDT via multiphoton excitation. The triplet state energy levels for all molecules have been determined by the triplet quenching method, phosphorescence measurements and DFT calculations. We find that the triplet energies of all the oligomers are sufficient to generate singlet oxygen, >94 kJ mol-1. However, low singlet oxygen quantum yields are observed for the tetramer and the octamer, as compared to the conjugated dimer and monomeric porphyrin, reflecting the decrease in triplet yield. Thus the conjugated porphyrin dimer is the most promising core structure for PDT applications via multiphoton excitation.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalPhotochemical and Photobiological Sciences
Volume6
Issue number6
DOIs
Publication statusPublished - 2007 Jun 15

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Porphyrins
oligomers
Oligomers
porphyrins
Electron energy levels
Photodynamic therapy
atomic energy levels
therapy
Singlet Oxygen
Dimers
dimers
Phosphorescence
Molecules
energy
Quantum yield
oxygen
phosphorescence
Discrete Fourier transforms
excitation
molecules

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry

Cite this

Kuimova, Marina K. ; Hoffmann, Markus ; Winters, Mikael U. ; Eng, Mattias ; Balaz, Milan ; Clark, Ian P. ; Collins, Hazel A. ; Tavender, Susan M. ; Wilson, Craig J. ; Albinsson, Bo ; Anderson, Harry L. ; Parker, Anthony W. ; Phillips, David. / Determination of the triplet state energies of a series of conjugated porphyrin oligomers. In: Photochemical and Photobiological Sciences. 2007 ; Vol. 6, No. 6. pp. 675-682.
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Kuimova, MK, Hoffmann, M, Winters, MU, Eng, M, Balaz, M, Clark, IP, Collins, HA, Tavender, SM, Wilson, CJ, Albinsson, B, Anderson, HL, Parker, AW & Phillips, D 2007, 'Determination of the triplet state energies of a series of conjugated porphyrin oligomers', Photochemical and Photobiological Sciences, vol. 6, no. 6, pp. 675-682. https://doi.org/10.1039/b700557a

Determination of the triplet state energies of a series of conjugated porphyrin oligomers. / Kuimova, Marina K.; Hoffmann, Markus; Winters, Mikael U.; Eng, Mattias; Balaz, Milan; Clark, Ian P.; Collins, Hazel A.; Tavender, Susan M.; Wilson, Craig J.; Albinsson, Bo; Anderson, Harry L.; Parker, Anthony W.; Phillips, David.

In: Photochemical and Photobiological Sciences, Vol. 6, No. 6, 15.06.2007, p. 675-682.

Research output: Contribution to journalArticle

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T1 - Determination of the triplet state energies of a series of conjugated porphyrin oligomers

AU - Kuimova, Marina K.

AU - Hoffmann, Markus

AU - Winters, Mikael U.

AU - Eng, Mattias

AU - Balaz, Milan

AU - Clark, Ian P.

AU - Collins, Hazel A.

AU - Tavender, Susan M.

AU - Wilson, Craig J.

AU - Albinsson, Bo

AU - Anderson, Harry L.

AU - Parker, Anthony W.

AU - Phillips, David

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N2 - We report a systematic study of the photophysical parameters relevant to photodynamic therapy (PDT) by a new type of sensitizers, conjugated porphyrin oligomers. Due to the strong nonlinear properties of oligomers containing 2, 4 and 8 porphyrin units, these molecules are attractive candidates for PDT via multiphoton excitation. The triplet state energy levels for all molecules have been determined by the triplet quenching method, phosphorescence measurements and DFT calculations. We find that the triplet energies of all the oligomers are sufficient to generate singlet oxygen, >94 kJ mol-1. However, low singlet oxygen quantum yields are observed for the tetramer and the octamer, as compared to the conjugated dimer and monomeric porphyrin, reflecting the decrease in triplet yield. Thus the conjugated porphyrin dimer is the most promising core structure for PDT applications via multiphoton excitation.

AB - We report a systematic study of the photophysical parameters relevant to photodynamic therapy (PDT) by a new type of sensitizers, conjugated porphyrin oligomers. Due to the strong nonlinear properties of oligomers containing 2, 4 and 8 porphyrin units, these molecules are attractive candidates for PDT via multiphoton excitation. The triplet state energy levels for all molecules have been determined by the triplet quenching method, phosphorescence measurements and DFT calculations. We find that the triplet energies of all the oligomers are sufficient to generate singlet oxygen, >94 kJ mol-1. However, low singlet oxygen quantum yields are observed for the tetramer and the octamer, as compared to the conjugated dimer and monomeric porphyrin, reflecting the decrease in triplet yield. Thus the conjugated porphyrin dimer is the most promising core structure for PDT applications via multiphoton excitation.

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