Detrimental effect of type 2 diabetes mellitus in a large case series of Parkinson's disease

Seok Jong Chung, Seun Jeon, Han Soo Yoo, G. Kim, Jungsu S. Oh, Jae Seung Kim, Alan C. Evans, Young H. Sohn, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Introduction: To investigate the effect of diabetes mellitus (DM) on the clinicoradiological features in patients with Parkinson's disease (PD). Methods: 671 patients with de novo PD were classified into two groups according to the presence of DM (106 with DM and 565 without). We performed inter-group comparative analyses of the striatal dopamine transporter (DAT) availability in all patients and level of cognitive performances in 312 patients (58 with DM and 254 without). Neuroimaging analyses of cortical thickness were performed in 42 patients with DM and 42 matched patients without DM. We assessed the longitudinal changes in the levodopa-equivalent dose (LED) across time in 549 patients who were treated for at least two years (86 with DM and 463 without) using a linear mixed model. Results: The PD patients with DM were older at the onset of parkinsonism and had more severely decreased baseline DAT availability in the caudate and ventral striatum than those without DM. The PD group with DM showed poorer performances in attention/working memory and frontal/executive function than the group without DM. Cortical thinning in the right inferomedial temporal lobe was observed in PD with DM group relative to PD without DM group. During follow-up, the PD patients with DM showed a more rapid longitudinal increase in LED than those without DM. Conclusion: Our results suggest that coexistent DM may have a detrimental effect on disease progression as well as baseline striatal dopamine loss, brain structural alterations, and cognitive performances in patients with PD.

Original languageEnglish
Pages (from-to)54-59
Number of pages6
JournalParkinsonism and Related Disorders
Volume64
DOIs
Publication statusPublished - 2019 Jul

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number: NRF-2018R1D1A1B07048959). Dr. Seun Jeon is the recipient of following fellowships that contribute to his support: Bourse Fonds de Recherche Sant? Qu?bec (FRQS, dossier 34240 & 259605) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute (240522). We would like to thank Sung-Woo Kim, Sujeong Jang, and Joon-Kyung Seong (Department of Bio-convergence Engineering, Korea University, Seoul, South Korea) for helping us prepare this article.

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number: NRF-2018R1D1A1B07048959 ). Dr. Seun Jeon is the recipient of following fellowships that contribute to his support: Bourse Fonds de Recherche Santé Québec (FRQS, dossier 34240 & 259605 ) and by Jeanne Timmins Costello Fellowship of the Montreal Neurological Institute ( 240522 ).

Publisher Copyright:
© 2018 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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