Development and validation of osteoporosis risk-assessment model for Korean men

Sun Min Oh, Bo Mi Song, Byung Ho Nam, Yumie Rhee, Seong Hwan Moon, Deog Young Kim, Dae Ryong Kang, Hyeon Chang Kim

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Abstract

Purpose: The aim of the present study was to develop an osteoporosis risk-assessment model to identify high-risk individuals among Korean men. Materials and Methods: The study used data from 1340 and 1110 men ≥50 years who participated in the 2009 and 2010 Korean National Health and Nutrition Examination Survey, respectively, for development and validation of an osteoporosis risk-assessment model. Osteoporosis was defined as T score ≤-2.5 at either the femoral neck or lumbar spine. Performance of the candidate models and the Osteoporosis Self-assessment Tool for Asian (OSTA) was compared with sensitivity, specificity, and area under the receiver operating characteristics curve (AUC). A net reclassification improvement was further calculated to compare the developed Korean Osteoporosis Risk-Assessment Model for Men (KORAM-M) with OSTA. Results: In the development dataset, the prevalence of osteoporosis was 8.1%. KORAM-M, consisting of age and body weight, had a sensitivity of 90.8%, a specificity of 42.4%, and an AUC of 0.666 with a cut-off score of -9. In the validation dataset, similar results were shown: sensitivity 87.9%, specificity 39.7%, and AUC 0.638. Additionally, risk categorization with KORAM-M showed improved reclassification over that of OSTA up to 22.8%. Conclusion: KORAM-M can be simply used as a pre-screening tool to identify candidates for dual energy X-ray absorptiometry tests.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalYonsei medical journal
Volume57
Issue number1
DOIs
Publication statusPublished - 2016 Jan

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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