Development and validation of the Korean version of the medication regimen complexity index

Sunmin Lee, Jun Young Jang, Seungwon Yang, Jongsung Hahn, Kyoung Lok Min, Eun hee Jung, Kyung sun Oh, Raejung Cho, Min Jung Chang

Research output: Contribution to journalArticle

Abstract

The medication regimen complexity index (MRCI), originally developed in English, is a reliable and valid tool to assess the complexity of pharmacotherapy. This study aimed to validate the Korean version of MRCI (MRCI-K). A cross-cultural methodological study comprising 335 discharged patients of a tertiary hospital in Korea was conducted. The translation process included translation into Korean by two clinical pharmacists, back translation by two native speakers, and a pretest of the tool, culminating in the Korean version of MRCI-K. Reliability analysis was assessed using inter-rater and test–retest reliability with 25 randomly selected patients. Convergent and discriminant validity analyses were conducted by correlating MRCI scores with medication number, age, sex, adverse drug reaction (ADR) reports, and length of stay. The criterion validity was confirmed through evaluation by a nine-member expert panel that subjectively ranked these regimens. The reliability analysis demonstrated excellent internal consistency (Cronbach’s α = 0.977), and the intraclass correlation coefficient exceeded 0.90 for all cases. The correlation coefficient for the number of medications was 0.955 (P < 0.001). Weak significant correlations were observed with age and length of stay. The MRCI-K group with ADR reports scored higher (mean, 31.8) than the group without ADR reports (mean, 27.3). The expert panel’s ranking had a stronger correlation with the MRCI ranking than the medication number ranking. MRCI-K has similar reliability and validity as MRCI and is useful for analyzing therapeutic regimens with potential applications in both practice and research in Korea.

Original languageEnglish
Article numbere0216805
JournalPloS one
Volume14
Issue number5
DOIs
Publication statusPublished - 2019 May 1

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Drug-Related Side Effects and Adverse Reactions
drug therapy
Korea
Reliability analysis
Length of Stay
Pharmaceutical Preparations
Drug therapy
Discriminant Analysis
Population Groups
Pharmacists
Tertiary Care Centers
Reproducibility of Results
Drug Therapy
Research
drugs
Korean Peninsula
cross cultural studies
Therapeutics
therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, Sunmin ; Jang, Jun Young ; Yang, Seungwon ; Hahn, Jongsung ; Min, Kyoung Lok ; Jung, Eun hee ; Oh, Kyung sun ; Cho, Raejung ; Chang, Min Jung. / Development and validation of the Korean version of the medication regimen complexity index. In: PloS one. 2019 ; Vol. 14, No. 5.
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Lee, S, Jang, JY, Yang, S, Hahn, J, Min, KL, Jung, EH, Oh, KS, Cho, R & Chang, MJ 2019, 'Development and validation of the Korean version of the medication regimen complexity index', PloS one, vol. 14, no. 5, e0216805. https://doi.org/10.1371/journal.pone.0216805

Development and validation of the Korean version of the medication regimen complexity index. / Lee, Sunmin; Jang, Jun Young; Yang, Seungwon; Hahn, Jongsung; Min, Kyoung Lok; Jung, Eun hee; Oh, Kyung sun; Cho, Raejung; Chang, Min Jung.

In: PloS one, Vol. 14, No. 5, e0216805, 01.05.2019.

Research output: Contribution to journalArticle

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