Development and validation of the Vitiligo Extent Score for a Target Area (VESTA) to assess the treatment response of a target lesion

the East Asia Vitiligo Association

Research output: Contribution to journalArticle

Abstract

Since localized treatment for vitiligo is as essential as systemic treatment, a reliable instrument for target evaluation is needed besides those for whole body evaluation. We developed the Vitiligo Extent Score for a Target Area (VESTA) using reference images of both marginal and perifollicular repigmentation to measure the repigmentation rate (%) in a target lesion. In the validation study, a total of 65 dermatologists in 10 institutes evaluated 17 pairs of vitiligo images (pre- and post-treatment) using both a rough estimate and the VESTA. The VESTA (concordance correlation coefficient: 0.949, 95% confidence interval [CI] 0.942–0.955) was significantly more accurate than the rough estimate (0.896, 95% CI: 0.883–0.908). It was also associated with better inter-rater reliability over the rough estimate, albeit not significant. The VESTA can afford intuitive, convenient, and reliable assessment of the treatment response in a target area, and would be useful in clinical practice as well as retrospective studies.

Original languageEnglish
JournalPigment Cell and Melanoma Research
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Vitiligo
Therapeutics
Confidence Intervals
Validation Studies
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

Cite this

@article{ed272a9688d64080afd29f0eab327b3e,
title = "Development and validation of the Vitiligo Extent Score for a Target Area (VESTA) to assess the treatment response of a target lesion",
abstract = "Since localized treatment for vitiligo is as essential as systemic treatment, a reliable instrument for target evaluation is needed besides those for whole body evaluation. We developed the Vitiligo Extent Score for a Target Area (VESTA) using reference images of both marginal and perifollicular repigmentation to measure the repigmentation rate ({\%}) in a target lesion. In the validation study, a total of 65 dermatologists in 10 institutes evaluated 17 pairs of vitiligo images (pre- and post-treatment) using both a rough estimate and the VESTA. The VESTA (concordance correlation coefficient: 0.949, 95{\%} confidence interval [CI] 0.942–0.955) was significantly more accurate than the rough estimate (0.896, 95{\%} CI: 0.883–0.908). It was also associated with better inter-rater reliability over the rough estimate, albeit not significant. The VESTA can afford intuitive, convenient, and reliable assessment of the treatment response in a target area, and would be useful in clinical practice as well as retrospective studies.",
author = "{the East Asia Vitiligo Association} and Bae, {Jung Min} and SangHo Oh and Kang, {Hee Young} and Ryoo, {Young Wook} and Lan, {Cheng Che E.} and Xiang, {Lei Hong} and Kim, {Ki Ho} and Tamio Suzuki and Ichiro Katayama and Lee, {Seung Chul}",
year = "2018",
month = "1",
day = "1",
doi = "10.1111/pcmr.12730",
language = "English",
journal = "Pigment Cell and Melanoma Research",
issn = "1755-1471",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Development and validation of the Vitiligo Extent Score for a Target Area (VESTA) to assess the treatment response of a target lesion

AU - the East Asia Vitiligo Association

AU - Bae, Jung Min

AU - Oh, SangHo

AU - Kang, Hee Young

AU - Ryoo, Young Wook

AU - Lan, Cheng Che E.

AU - Xiang, Lei Hong

AU - Kim, Ki Ho

AU - Suzuki, Tamio

AU - Katayama, Ichiro

AU - Lee, Seung Chul

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Since localized treatment for vitiligo is as essential as systemic treatment, a reliable instrument for target evaluation is needed besides those for whole body evaluation. We developed the Vitiligo Extent Score for a Target Area (VESTA) using reference images of both marginal and perifollicular repigmentation to measure the repigmentation rate (%) in a target lesion. In the validation study, a total of 65 dermatologists in 10 institutes evaluated 17 pairs of vitiligo images (pre- and post-treatment) using both a rough estimate and the VESTA. The VESTA (concordance correlation coefficient: 0.949, 95% confidence interval [CI] 0.942–0.955) was significantly more accurate than the rough estimate (0.896, 95% CI: 0.883–0.908). It was also associated with better inter-rater reliability over the rough estimate, albeit not significant. The VESTA can afford intuitive, convenient, and reliable assessment of the treatment response in a target area, and would be useful in clinical practice as well as retrospective studies.

AB - Since localized treatment for vitiligo is as essential as systemic treatment, a reliable instrument for target evaluation is needed besides those for whole body evaluation. We developed the Vitiligo Extent Score for a Target Area (VESTA) using reference images of both marginal and perifollicular repigmentation to measure the repigmentation rate (%) in a target lesion. In the validation study, a total of 65 dermatologists in 10 institutes evaluated 17 pairs of vitiligo images (pre- and post-treatment) using both a rough estimate and the VESTA. The VESTA (concordance correlation coefficient: 0.949, 95% confidence interval [CI] 0.942–0.955) was significantly more accurate than the rough estimate (0.896, 95% CI: 0.883–0.908). It was also associated with better inter-rater reliability over the rough estimate, albeit not significant. The VESTA can afford intuitive, convenient, and reliable assessment of the treatment response in a target area, and would be useful in clinical practice as well as retrospective studies.

UR - http://www.scopus.com/inward/record.url?scp=85052933156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052933156&partnerID=8YFLogxK

U2 - 10.1111/pcmr.12730

DO - 10.1111/pcmr.12730

M3 - Article

C2 - 30117287

AN - SCOPUS:85052933156

JO - Pigment Cell and Melanoma Research

JF - Pigment Cell and Melanoma Research

SN - 1755-1471

ER -