This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n=5), a drug-free hybrid stent (group 2, n=5), a 50% (50: 100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n=5), and a 30% (30: 100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n=5). We performed follow-up angiography and intravascular ultrasonography (IVUS) at 4 and 8 weeks. In a comparison of groups 1, 2, 3, and 4, less diameter stenosis was observed in the angiographic analysis for group 4 at the 4-week follow-up (19.0% ± 12.7% versus 39.3% ± 18.1% versus 46.8% ± 38.0% versus 4.8% ± 4.2%, resp.; p=0.032). IVUS findings further suggested that the neointima of the patients in group 4 tended to be lesser than those of the others. Our new biodegradable 30% PTX/PLGA (slow-releasing form) stent showed more favorable results for patency than the other stent types.
Bibliographical noteFunding Information:
This paper is based on the first author's doctoral dissertation. This study was supported by research grants fromthe Korea Healthcare Technology RandD Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (nos. A102064 and A085136), National Research Foundation of Korea (no. 2015R1A2A2A01002731), and Cardiovascular Research Center, Seoul, Republic of Korea
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)