Development of a Shape-Memory Tube to Prevent Vascular Stenosis

Yong Cheol Shin, Jung Bok Lee, Dae Hyun Kim, Taeyoung Kim, Grant Alexander, Young Min Shin, Ju Young Park, Sewoom Baek, Jeong Kee Yoon, Yong Jae Lee, Gyeung Mi Seon, Mi Hee Lee, Mi Lan Kang, Woo Soon Jang, Jong Chul Park, Ho Wook Jun, Yong Tae Kim, Hak Joon Sung

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2 Citations (Scopus)

Abstract

Inserting a graft into vessels with different diameters frequently causes severe damage to the host vessels. Poor flow patency is an unresolved issue in grafts, particularly those with diameters less than 6 mm, because of vessel occlusion caused by disturbed blood flow following fast clotting. Herein, successful patency in the deployment of an ≈2 mm diameter graft into a porcine vessel is reported. A new library of property-tunable shape-memory polymers that prevent vessel damage by expanding the graft diameter circumferentially upon implantation is presented. The polymers undergo seven consecutive cycles of strain energy-preserved shape programming. Moreover, the new graft tube, which features a diffuser shape, minimizes disturbed flow formation and prevents thrombosis because its surface is coated with nitric-oxide-releasing peptides. Improved patency in a porcine vessel for 18 d is demonstrated while occlusive vascular remodeling occurs. These insights will help advance vascular graft design.

Original languageEnglish
Article number1904476
JournalAdvanced Materials
Volume31
Issue number41
DOIs
Publication statusPublished - 2019 Oct 1

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Shin, Y. C., Lee, J. B., Kim, D. H., Kim, T., Alexander, G., Shin, Y. M., Park, J. Y., Baek, S., Yoon, J. K., Lee, Y. J., Seon, G. M., Lee, M. H., Kang, M. L., Jang, W. S., Park, J. C., Jun, H. W., Kim, Y. T., & Sung, H. J. (2019). Development of a Shape-Memory Tube to Prevent Vascular Stenosis. Advanced Materials, 31(41), [1904476]. https://doi.org/10.1002/adma.201904476