Development of aggressive squamous cell carcinoma in epidermodysplasia verruciformis associated with human papillomavirus type 22b

Taegyun Kim, Jae Chan Park, Mi Ryung Roh, Jin Mo Park, Se Heon Kim, Nam Hoon Cho, Min Geol Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Epidermodysplasia verruciformis (EV) is a rare genetic disease characterized by abnormal susceptibility to infection with EV-related human papillomavirus (HPV), now known as the β-papillomavirus (β-PV). Clinically specific β-PV-type-associated EV, especially HPV-5 and -8, shows a high rate of progression to squamous cell carcinoma (SCC). In this report, we describe a 39-year-old Korean man with HPV-22b-associated EV who developed a rapidly progressing SCC. The patient presented with a huge destructive mass on the nose. Histopathological evaluation of the mass was compatible with well-differentiated SCC. HPV typing results from both EV and SCC specimens demonstrated HPV-22b which has not been considered to be associated with SCC in EV patients so far. The patient underwent surgical excision and postoperative radiotherapy for locoregional control. This is the first report presenting the association of an SCC arising from previous EV with HPV-22b infection only.

Original languageEnglish
Pages (from-to)326-328
Number of pages3
JournalDermatology
Volume220
Issue number4
DOIs
Publication statusPublished - 2010 Jun

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Epidermodysplasia Verruciformis
Squamous Cell Carcinoma
Inborn Genetic Diseases
Papillomavirus Infections
Rare Diseases
Nose
Radiotherapy

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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title = "Development of aggressive squamous cell carcinoma in epidermodysplasia verruciformis associated with human papillomavirus type 22b",
abstract = "Epidermodysplasia verruciformis (EV) is a rare genetic disease characterized by abnormal susceptibility to infection with EV-related human papillomavirus (HPV), now known as the β-papillomavirus (β-PV). Clinically specific β-PV-type-associated EV, especially HPV-5 and -8, shows a high rate of progression to squamous cell carcinoma (SCC). In this report, we describe a 39-year-old Korean man with HPV-22b-associated EV who developed a rapidly progressing SCC. The patient presented with a huge destructive mass on the nose. Histopathological evaluation of the mass was compatible with well-differentiated SCC. HPV typing results from both EV and SCC specimens demonstrated HPV-22b which has not been considered to be associated with SCC in EV patients so far. The patient underwent surgical excision and postoperative radiotherapy for locoregional control. This is the first report presenting the association of an SCC arising from previous EV with HPV-22b infection only.",
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Development of aggressive squamous cell carcinoma in epidermodysplasia verruciformis associated with human papillomavirus type 22b. / Kim, Taegyun; Park, Jae Chan; Roh, Mi Ryung; Park, Jin Mo; Kim, Se Heon; Cho, Nam Hoon; Lee, Min Geol.

In: Dermatology, Vol. 220, No. 4, 06.2010, p. 326-328.

Research output: Contribution to journalArticle

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AU - Cho, Nam Hoon

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