Development of an HbA1c-based conversion equation for estimating glycated albumin in a Korean population with a wide range of glucose intolerance

Chang Hee Jung, You Cheol Hwang, Kwang Joon Kim, Bong Soo Cha, Cheol Young Park, Won Seon Jeon, Jae Hyeon Kim, Sang Man Jin, Sang Youl Rhee, Jeong Taek Woo, Byung Wan Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Compared to the golden standard glycation index of HbA1c, glycated albumin (GA) has potentials for assessing insulin secretory dysfunction and glycemic fluctuation as well as predicting diabetic vascular complications. However, the reference ranges of GA and a conversion equation need to be clearly defined. We designed this study to determine the reference ranges in patients with normal glucose tolerance (NGT) based on conventional measures of glycemic status and to devise a conversion equation for calculating HbA1c and GA in a Korean population. Methodology/Principal Findings: In this multicenter, retrospective, cross-sectional study, we recruited antidiabetic drug-naïve patients with available glycemic variables including HbA1c, GA, and fasting plasma glucose regardless of glucose status. For the reference interval of serum GA, 5th to 95th percentile value of GA in subjects with NGT was adopted. The conversion equation between HbA1c and GA was devised using an estimating regression model with unknown breakpoints method. The reference range for GA was 9.0-14.0% in 2043 subjects. The 95th percentile responding values for FPG, and HbA1c were approximately 5.49 mmol/l, and 5.6%, respectively. The significant glycemic turning points were 5.868% HbA1c and 12.2% GA. The proposed conversion equation for below and above the turning point were GA (%) = 6.960+0.8963 x HbA1c (%) and GA (%) = -9.609+3.720 x HbA1c (%), respectively. Conclusions/Significance: These results should be helpful in future studies on the clinical implications of high GA relative to HbA1c and the clinical implementation of diabetes management.

Original languageEnglish
Article numbere95729
JournalPloS one
Volume9
Issue number4
DOIs
Publication statusPublished - 2014 Apr 22

Fingerprint

glycohemoglobin
Glucose Intolerance
albumins
Glucose
glucose
Population
Reference Values
glucose tolerance
glycosylated serum albumin
hypoglycemic agents
Diabetic Angiopathies
glycation
Medical problems
Hypoglycemic Agents
blood vessels
cross-sectional studies
Serum Albumin
fasting
diabetes
Fasting

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Jung, Chang Hee ; Hwang, You Cheol ; Kim, Kwang Joon ; Cha, Bong Soo ; Park, Cheol Young ; Jeon, Won Seon ; Kim, Jae Hyeon ; Jin, Sang Man ; Rhee, Sang Youl ; Woo, Jeong Taek ; Lee, Byung Wan. / Development of an HbA1c-based conversion equation for estimating glycated albumin in a Korean population with a wide range of glucose intolerance. In: PloS one. 2014 ; Vol. 9, No. 4.
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abstract = "Background: Compared to the golden standard glycation index of HbA1c, glycated albumin (GA) has potentials for assessing insulin secretory dysfunction and glycemic fluctuation as well as predicting diabetic vascular complications. However, the reference ranges of GA and a conversion equation need to be clearly defined. We designed this study to determine the reference ranges in patients with normal glucose tolerance (NGT) based on conventional measures of glycemic status and to devise a conversion equation for calculating HbA1c and GA in a Korean population. Methodology/Principal Findings: In this multicenter, retrospective, cross-sectional study, we recruited antidiabetic drug-na{\"i}ve patients with available glycemic variables including HbA1c, GA, and fasting plasma glucose regardless of glucose status. For the reference interval of serum GA, 5th to 95th percentile value of GA in subjects with NGT was adopted. The conversion equation between HbA1c and GA was devised using an estimating regression model with unknown breakpoints method. The reference range for GA was 9.0-14.0{\%} in 2043 subjects. The 95th percentile responding values for FPG, and HbA1c were approximately 5.49 mmol/l, and 5.6{\%}, respectively. The significant glycemic turning points were 5.868{\%} HbA1c and 12.2{\%} GA. The proposed conversion equation for below and above the turning point were GA ({\%}) = 6.960+0.8963 x HbA1c ({\%}) and GA ({\%}) = -9.609+3.720 x HbA1c ({\%}), respectively. Conclusions/Significance: These results should be helpful in future studies on the clinical implications of high GA relative to HbA1c and the clinical implementation of diabetes management.",
author = "Jung, {Chang Hee} and Hwang, {You Cheol} and Kim, {Kwang Joon} and Cha, {Bong Soo} and Park, {Cheol Young} and Jeon, {Won Seon} and Kim, {Jae Hyeon} and Jin, {Sang Man} and Rhee, {Sang Youl} and Woo, {Jeong Taek} and Lee, {Byung Wan}",
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Development of an HbA1c-based conversion equation for estimating glycated albumin in a Korean population with a wide range of glucose intolerance. / Jung, Chang Hee; Hwang, You Cheol; Kim, Kwang Joon; Cha, Bong Soo; Park, Cheol Young; Jeon, Won Seon; Kim, Jae Hyeon; Jin, Sang Man; Rhee, Sang Youl; Woo, Jeong Taek; Lee, Byung Wan.

In: PloS one, Vol. 9, No. 4, e95729, 22.04.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Development of an HbA1c-based conversion equation for estimating glycated albumin in a Korean population with a wide range of glucose intolerance

AU - Jung, Chang Hee

AU - Hwang, You Cheol

AU - Kim, Kwang Joon

AU - Cha, Bong Soo

AU - Park, Cheol Young

AU - Jeon, Won Seon

AU - Kim, Jae Hyeon

AU - Jin, Sang Man

AU - Rhee, Sang Youl

AU - Woo, Jeong Taek

AU - Lee, Byung Wan

PY - 2014/4/22

Y1 - 2014/4/22

N2 - Background: Compared to the golden standard glycation index of HbA1c, glycated albumin (GA) has potentials for assessing insulin secretory dysfunction and glycemic fluctuation as well as predicting diabetic vascular complications. However, the reference ranges of GA and a conversion equation need to be clearly defined. We designed this study to determine the reference ranges in patients with normal glucose tolerance (NGT) based on conventional measures of glycemic status and to devise a conversion equation for calculating HbA1c and GA in a Korean population. Methodology/Principal Findings: In this multicenter, retrospective, cross-sectional study, we recruited antidiabetic drug-naïve patients with available glycemic variables including HbA1c, GA, and fasting plasma glucose regardless of glucose status. For the reference interval of serum GA, 5th to 95th percentile value of GA in subjects with NGT was adopted. The conversion equation between HbA1c and GA was devised using an estimating regression model with unknown breakpoints method. The reference range for GA was 9.0-14.0% in 2043 subjects. The 95th percentile responding values for FPG, and HbA1c were approximately 5.49 mmol/l, and 5.6%, respectively. The significant glycemic turning points were 5.868% HbA1c and 12.2% GA. The proposed conversion equation for below and above the turning point were GA (%) = 6.960+0.8963 x HbA1c (%) and GA (%) = -9.609+3.720 x HbA1c (%), respectively. Conclusions/Significance: These results should be helpful in future studies on the clinical implications of high GA relative to HbA1c and the clinical implementation of diabetes management.

AB - Background: Compared to the golden standard glycation index of HbA1c, glycated albumin (GA) has potentials for assessing insulin secretory dysfunction and glycemic fluctuation as well as predicting diabetic vascular complications. However, the reference ranges of GA and a conversion equation need to be clearly defined. We designed this study to determine the reference ranges in patients with normal glucose tolerance (NGT) based on conventional measures of glycemic status and to devise a conversion equation for calculating HbA1c and GA in a Korean population. Methodology/Principal Findings: In this multicenter, retrospective, cross-sectional study, we recruited antidiabetic drug-naïve patients with available glycemic variables including HbA1c, GA, and fasting plasma glucose regardless of glucose status. For the reference interval of serum GA, 5th to 95th percentile value of GA in subjects with NGT was adopted. The conversion equation between HbA1c and GA was devised using an estimating regression model with unknown breakpoints method. The reference range for GA was 9.0-14.0% in 2043 subjects. The 95th percentile responding values for FPG, and HbA1c were approximately 5.49 mmol/l, and 5.6%, respectively. The significant glycemic turning points were 5.868% HbA1c and 12.2% GA. The proposed conversion equation for below and above the turning point were GA (%) = 6.960+0.8963 x HbA1c (%) and GA (%) = -9.609+3.720 x HbA1c (%), respectively. Conclusions/Significance: These results should be helpful in future studies on the clinical implications of high GA relative to HbA1c and the clinical implementation of diabetes management.

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