TY - JOUR
T1 - Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells
AU - Lee, John Hwan
AU - Kim, Yoojin
AU - Yoon, Ye Eun
AU - Kim, Yong Jin
AU - Oh, Seong Geun
AU - Jang, Jae Hyung
AU - Kim, Eunmi
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/7/25
Y1 - 2017/7/25
N2 - We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components—AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein BIM, which uses HSPG as its primary receptor, to target HSPG-overexpressing melanoma cells. This combination treatment showed promising results in vitro, inducing apoptosis in human melanoma cells. This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies.
AB - We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components—AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein BIM, which uses HSPG as its primary receptor, to target HSPG-overexpressing melanoma cells. This combination treatment showed promising results in vitro, inducing apoptosis in human melanoma cells. This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies.
UR - http://www.scopus.com/inward/record.url?scp=85015339492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015339492&partnerID=8YFLogxK
U2 - 10.1016/j.nbt.2017.02.001
DO - 10.1016/j.nbt.2017.02.001
M3 - Article
C2 - 28179151
AN - SCOPUS:85015339492
VL - 37
SP - 194
EP - 199
JO - Genetic Analysis - Biomolecular Engineering
JF - Genetic Analysis - Biomolecular Engineering
SN - 1871-6784
ER -