Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells

John Hwan Lee, Yoojin Kim, Ye Eun Yoon, Yong Jin Kim, Seong Geun Oh, Jae Hyung Jang, Eunmi Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components—AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein BIM, which uses HSPG as its primary receptor, to target HSPG-overexpressing melanoma cells. This combination treatment showed promising results in vitro, inducing apoptosis in human melanoma cells. This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalNew Biotechnology
Volume37
DOIs
Publication statusPublished - 2017 Jul 25

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Molecular Biology

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