Development of Korean standard brain templates

Sung Lee Jae, Soo Lee Dong, Jinsu Kim, Kyeong Kim Yu, Eunjoo Kang, Hyejin Kang, Wook Kang Keon, Min Lee Jong, Jae Jin Kim, Hae Jeong Park, Soo Kwon Jun, I. Kim Sun, Woo Yoo Tae, Kee Hyun Chang, Chul Lee Myung

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49 Citations (Scopus)

Abstract

We developed age, gender and ethnic specific brain templates based on MR and Positron-Emission Tomography (PET) images of Korean normal volunteers. Seventy-eight normal right-handed volunteers (M/F=49/29) underwent 3D T1-weighted SPGR MR and F-18-FDG PET scans. For the generation of standard templates, an optimal target brain that has the average global hemispheric shape was selected for each gender. MR images were then spatially normalized by linear transformation to the target brains, and normalization parameters were reapplied to PET images. Subjects were subdivided into 2 groups for each gender: the young/midlife (<55 yr) and the elderly groups. Young and elderly MRI/PET templates were composed by averaging the spatially normalized images. Korean templates showed different shapes and sizes (mean length, width, and height of the brains were 16.5, 14.3 and 12.1 cm for man, and 15.6, 13.5 and 11.4 cm for woman) from the template based on Caucasian (18.3, 14.2, and 13.3 cm). MRI and PET templates developed in this study will provide the framework for more accurate stereotactic standardization and anatomical localization.

Original languageEnglish
Pages (from-to)483-488
Number of pages6
JournalJournal of Korean medical science
Volume20
Issue number3
Publication statusPublished - 2005 Jun 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Jae, S. L., Dong, S. L., Kim, J., Yu, K. K., Kang, E., Kang, H., Keon, W. K., Jong, M. L., Kim, J. J., Park, H. J., Jun, S. K., Sun, I. K., Tae, W. Y., Chang, K. H., & Myung, C. L. (2005). Development of Korean standard brain templates. Journal of Korean medical science, 20(3), 483-488.