Development of lidocaine-loaded dissolving microneedle for rapid and efficient local anesthesia

Huisuk Yang, Geonwoo Kang, Mingyu Jang, Daniel Junmin Um, Jiwoo Shin, Hyeonjun Kim, Jintae Hong, Hyunji Jung, Hyemyoung Ahn, Seongdae Gong, Chisong Lee, Ui Won Jung, Hyungil Jung

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Lidocaine is a local anesthetic agent used in the form of injection and topical cream. However, these formulation types have limitations of being either painful or slow-acting, thereby hindering effective and complete clinical performance of lidocaine. Dissolving microneedles (DMNs) are used to overcome these limitations owing to their fast onset time and minimally invasive administration methods. Using hyaluronic acid and lidocaine to produce the drug solution, a lidocaine HCl encapsulated DMN (Li-DMN) was fabricated by centrifugal lithography. The drug delivery rate and local anesthetic quality of Li-DMNs were evaluated using the pig cadaver insertion test and Von Frey behavior test. Results showed that Li-DMNs could deliver sufficient lidocaine for anesthesia that is required to be utilized for clinical level. Results from the von Frey test showed that the anesthetic effect of Li-DMNs was observed within 10 min after administration, thus confirming fast onset time. A toxicity test for appropriate clinical application standard was conducted with a microbial limit test and an animal skin irritation test, showing absence of skin irritation and irritation-related microorganisms. Overall, Li-DMN is a possible alternative drug delivery method for local anesthesia, meeting the requirements for clinical conditions and overcoming the drawbacks of other conventional lidocaine administration methods.

Original languageEnglish
Article number1067
Pages (from-to)1-13
Number of pages13
JournalPharmaceutics
Volume12
Issue number11
DOIs
Publication statusPublished - 2020 Nov

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0625) and a grant of the Korea Startup Scale-Up Package through the Ministry of SMEs & Startups and KISED, Republic of Korea (grant number: 10220767).

Funding Information:
Funding: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0625) and a grant of the Korea Startup Scale-Up Package through the Ministry of SMEs & Startups and KISED, Republic of Korea (grant number: 10220767) Conflicts of Interest: D.J.U., J.S., C.L. and U.-W.J. declare no conflict of interest. H.Y., G.K., M.J., H.K., J.H., H.A, and S.G. are employees of JUVIC Inc., which develops microneedle-based products and H.J. is an inventor of patents that have been or may be licensed to JUVIC Inc. and is a shareholder of JUVIC Inc. These potential conflicts of interest have been disclosed and are being managed by Yonsei University. The company had no role in the writing of the manuscript, and in the decision to publish the results.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Development of lidocaine-loaded dissolving microneedle for rapid and efficient local anesthesia'. Together they form a unique fingerprint.

Cite this