Development of thyroid-associated ophthalmopathy in patients who underwent total thyroidectomy

Sun Young Jang, Ka Hyun Lee, Jong Rok Oh, Bo Yeon Kim, Jin Sook Yoon

Research output: Contribution to journalArticle

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Abstract

Purpose: To report clinical characteristics of thyroid-associated ophthalmopathy (TAO) in patients who previously underwent total thyroidectomy for thyroid cancer or a benign mass of the thyroid. Materials and Methods: Of the patients who were diagnosed with TAO from March 2008 to March 2012, we performed a retrospective chart review on those who had undergone total thyroidectomy for thyroid cancer or a benign mass of the thyroid before the occurrence of ophthalmopathy. Results: Of the 206 patients diagnosed with TAO, seven (3.4%) met the inclusion criteria. The mean age of the subjects was 47.4 years, and all were female. Six patients were diagnosed with papillary thyroid cancer, and one was diagnosed with a benign mass. The duration between total thyroidectomy and onset of TAO ranged from 3–120 months (median 48 months). Ophthalmic manifestations varied among cases. Except for the patient who was diagnosed with a benign mass, all patients showed hyperthyroid status and were under Synthroid hormone treatment at the time of TAO development. Five of these six patients had positive levels of thyroid-stimulating hormone (TSH) receptor autoantibodies. Conclusion: TAO rarely develops after total thyroidectomy, and the mechanism of TAO occurrence is unclear. However, most patients showed abnormalities in thyroid function and TSH receptor autoantibodies.

Original languageEnglish
Pages (from-to)1389-1394
Number of pages6
JournalYonsei medical journal
Volume56
Issue number5
DOIs
Publication statusPublished - 2015 Sep 1

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Graves Ophthalmopathy
Thyroidectomy
Thyrotropin Receptors
Thyroid Gland
Thyroid Neoplasms
Autoantibodies
Eye Manifestations
Hyperthyroidism
Thyroxine
Hormones

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jang, Sun Young ; Lee, Ka Hyun ; Oh, Jong Rok ; Kim, Bo Yeon ; Yoon, Jin Sook. / Development of thyroid-associated ophthalmopathy in patients who underwent total thyroidectomy. In: Yonsei medical journal. 2015 ; Vol. 56, No. 5. pp. 1389-1394.
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Development of thyroid-associated ophthalmopathy in patients who underwent total thyroidectomy. / Jang, Sun Young; Lee, Ka Hyun; Oh, Jong Rok; Kim, Bo Yeon; Yoon, Jin Sook.

In: Yonsei medical journal, Vol. 56, No. 5, 01.09.2015, p. 1389-1394.

Research output: Contribution to journalArticle

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