Development of water-soluble single-crystalline TiO2 nanoparticles for photocatalytic cancer-cell treatment

Jung Wook Seo, Heawon Chung, Mi Yun Kim, Jeonggi Lee, In Hong Choi, Jinwoo Cheon

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

The fabrication of water-soluble and biocompatible TiO2 nanoparticles and their photocatalytic capabilities for applications to skin cancer cells, are discussed. TiO2 nanoparticles, synthesized by a high-temperature nonhydrolytic method, are single-crystalline anatase, and are insoluble in water due to hydrophobic capping ligands. To make them water soluble, surface modification of these nanoparticles was performed, and these particles were coated with DMSA (2,3-dimercaptosuccinic acid). These nanoparticles represented superior photocatalytic capabilities to be applicable for the cancer cell treatment to that of the commercial Degussa P-25. These capabilities were attributed to the high surface-to-volume ratio and single crystallinity of these TiO2 nanoparticles. These qualities increased the photocatalytic efficiency by increasing the number of catalytic sites and also enhancing the delocalization of carriers to reduce electron-hole pair recombination.

Original languageEnglish
Pages (from-to)850-853
Number of pages4
JournalSmall
Volume3
Issue number5
DOIs
Publication statusPublished - 2007 May 1

Fingerprint

Nanoparticles
Crystalline materials
Water
Neoplasms
Cells
Succimer
Skin Neoplasms
Titanium dioxide
Genetic Recombination
Surface treatment
Catalytic Domain
Skin
Ligands
Electrons
Fabrication
Temperature
Acids

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Seo, Jung Wook ; Chung, Heawon ; Kim, Mi Yun ; Lee, Jeonggi ; Choi, In Hong ; Cheon, Jinwoo. / Development of water-soluble single-crystalline TiO2 nanoparticles for photocatalytic cancer-cell treatment. In: Small. 2007 ; Vol. 3, No. 5. pp. 850-853.
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Development of water-soluble single-crystalline TiO2 nanoparticles for photocatalytic cancer-cell treatment. / Seo, Jung Wook; Chung, Heawon; Kim, Mi Yun; Lee, Jeonggi; Choi, In Hong; Cheon, Jinwoo.

In: Small, Vol. 3, No. 5, 01.05.2007, p. 850-853.

Research output: Contribution to journalArticle

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T1 - Development of water-soluble single-crystalline TiO2 nanoparticles for photocatalytic cancer-cell treatment

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AU - Chung, Heawon

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AU - Choi, In Hong

AU - Cheon, Jinwoo

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AB - The fabrication of water-soluble and biocompatible TiO2 nanoparticles and their photocatalytic capabilities for applications to skin cancer cells, are discussed. TiO2 nanoparticles, synthesized by a high-temperature nonhydrolytic method, are single-crystalline anatase, and are insoluble in water due to hydrophobic capping ligands. To make them water soluble, surface modification of these nanoparticles was performed, and these particles were coated with DMSA (2,3-dimercaptosuccinic acid). These nanoparticles represented superior photocatalytic capabilities to be applicable for the cancer cell treatment to that of the commercial Degussa P-25. These capabilities were attributed to the high surface-to-volume ratio and single crystallinity of these TiO2 nanoparticles. These qualities increased the photocatalytic efficiency by increasing the number of catalytic sites and also enhancing the delocalization of carriers to reduce electron-hole pair recombination.

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