Developmental properties of the Hertwig's epithelial root sheath in mice

H. Yamamoto, S. W. Cho, E. J. Kim, J. Y. Kim, N. Fujiwara, Hansung Jung

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Hertwig's epithelial root sheath (HERS) plays an important role in tooth root formation. In this study, we examined root formation of the first molar in mice, focusing on cell proliferation, cell death, cell migration, and the expression patterns of the signaling molecules, including glycoproteins and proteoglycans between PN8 and PN26. The number of HERS cells decreased during root formation, although HERS retained total length until PN15. The migration of HERS cells did not occur during root formation. Moreover, the immunopositive reaction of laminin beta-3 and syndecan-1 in HERS indicates that both cell adhesion and cell proliferation are essential for HERS development. Bmp-2, Bmp-4, and Msx-2 were expressed in HERS cells during root formation. We also developed an in vitro culture system for investigating the periodontium and suggest that this system provides an excellent vehicle for full exploration, and hence improved understanding, of the development and regeneration of the periodontium. Together, our results provide a comprehensive model describing the morphogenesis of early root development in vertebrates.

Original languageEnglish
Pages (from-to)688-692
Number of pages5
JournalJournal of Dental Research
Volume83
Issue number9
DOIs
Publication statusPublished - 2004 Jan 1

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Periodontium
Syndecan-1
Cell Proliferation
Tooth Root
Laminin
Proteoglycans
Morphogenesis
Cell Adhesion
Cell Movement
Vertebrates
Regeneration
Glycoproteins
Cell Death
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Yamamoto, H. ; Cho, S. W. ; Kim, E. J. ; Kim, J. Y. ; Fujiwara, N. ; Jung, Hansung. / Developmental properties of the Hertwig's epithelial root sheath in mice. In: Journal of Dental Research. 2004 ; Vol. 83, No. 9. pp. 688-692.
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Developmental properties of the Hertwig's epithelial root sheath in mice. / Yamamoto, H.; Cho, S. W.; Kim, E. J.; Kim, J. Y.; Fujiwara, N.; Jung, Hansung.

In: Journal of Dental Research, Vol. 83, No. 9, 01.01.2004, p. 688-692.

Research output: Contribution to journalArticle

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