Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages

Eun Kyung Lim, Eunji Jang, Bongjune Kim, Jihye Choi, Kwangyeol Lee, Jinsuck Suh, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophage via MR imaging.

Original languageEnglish
Pages (from-to)12473-12478
Number of pages6
JournalJournal of Materials Chemistry
Volume21
Issue number33
DOIs
Publication statusPublished - 2011 Sep 7

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Dextran
Macrophages
Nanoclusters
Magnetic resonance
Dextrans
Contrast Media
Imaging techniques
Nanocrystals
Biocompatibility
Encapsulation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Chemistry

Cite this

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abstract = "We fabricated dextran-coated magnetic nanoclusters (Dex-MNCs) for targeted magnetic resonance (MR) imaging of inflammatory macrophages. Dex-MNCs were prepared through encapsulation of hydrophobic magnetic nanocrystals (MNCs) by pyrenyl dextran in order that MNCs could achieve increased colloidal stability in aqueous phase as well as strongly interact with macrophages. Dex-MNCs exhibited biocompatibility and sufficient targeting efficiency against macrophages with strengthened MR contrast effect from in vitro/in vivo studies. Considering these results, we confirmed that Dex-MNCs could accurately detect inflammatory macrophage via MR imaging.",
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Dextran-coated magnetic nanoclusters as highly sensitive contrast agents for magnetic resonance imaging of inflammatory macrophages. / Lim, Eun Kyung; Jang, Eunji; Kim, Bongjune; Choi, Jihye; Lee, Kwangyeol; Suh, Jinsuck; Huh, yongmin; Haam, Seungjoo.

In: Journal of Materials Chemistry, Vol. 21, No. 33, 07.09.2011, p. 12473-12478.

Research output: Contribution to journalArticle

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AU - Lim, Eun Kyung

AU - Jang, Eunji

AU - Kim, Bongjune

AU - Choi, Jihye

AU - Lee, Kwangyeol

AU - Suh, Jinsuck

AU - Huh, yongmin

AU - Haam, Seungjoo

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