The folded structures of peptidomimetics containing dimers of oxanipecotic acid (Oxa) in loop segments were characterized and compared with those of the corresponding nipecotic acid (Nip)-based ones. According to structural studies using FT-IR and NMR spectroscopies, di-oxanipecotic acid adopted more stable turn conformations than di-nipecotic acid, and for tetramers, L,(S)-Oxa,(S)-Oxa,L and L,(S)-Oxa,(R)-Oxa,L formed hairpin-like structures but only L,(R)-Nip,(S)-Nip,L promoted the stable folded conformations.
Bibliographical noteFunding Information:
This work was supported by a grant of the Center for Integrated Molecular Systems (KOSEF). We thank Dr. Yong Jun Chung for several helpful discussions concerning IR studies.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry