Abstract
Hepatitis B virus (HBV) infection is a major global health problems leading to severe liver disease such as cirrhosis and hepatocellular carcinoma (HCC). HBV is a circular, partly double-stranded DNA virus with various serological markers: hepatitis B surface antigen (HBsAg) and anti-HBs, anti-HBc IgM and IgG, and hepatitis B e antigen (HBeAg) and anti-HBe. It is transmitted by sexual, parenteral and vertical route. One significant method to diminish the burden of this disease is timely diagnosis of acute, chronic and occult cases of HBV. First step of HBV diagnosis is achieved by using serological markers for detecting antigens and antibodies. In order to verify first step of diagnosis, to quantify viral load and to identify genotypes, quantitative or qualitative molecular tests are used. In this article, the serological and molecular tests for diagnosis of HBV infection will be reviewed.
| Original language | English |
|---|---|
| Article number | 338 |
| Journal | Annals of Translational Medicine |
| Volume | 4 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 2016 Sep |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Diagnosis of hepatitis B. / Song, Jeong Eun; Kim, Do Young.
In: Annals of Translational Medicine, Vol. 4, No. 18, 338, 09.2016.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Diagnosis of hepatitis B
AU - Song, Jeong Eun
AU - Kim, Do Young
PY - 2016/9
Y1 - 2016/9
N2 - Hepatitis B virus (HBV) infection is a major global health problems leading to severe liver disease such as cirrhosis and hepatocellular carcinoma (HCC). HBV is a circular, partly double-stranded DNA virus with various serological markers: hepatitis B surface antigen (HBsAg) and anti-HBs, anti-HBc IgM and IgG, and hepatitis B e antigen (HBeAg) and anti-HBe. It is transmitted by sexual, parenteral and vertical route. One significant method to diminish the burden of this disease is timely diagnosis of acute, chronic and occult cases of HBV. First step of HBV diagnosis is achieved by using serological markers for detecting antigens and antibodies. In order to verify first step of diagnosis, to quantify viral load and to identify genotypes, quantitative or qualitative molecular tests are used. In this article, the serological and molecular tests for diagnosis of HBV infection will be reviewed.
AB - Hepatitis B virus (HBV) infection is a major global health problems leading to severe liver disease such as cirrhosis and hepatocellular carcinoma (HCC). HBV is a circular, partly double-stranded DNA virus with various serological markers: hepatitis B surface antigen (HBsAg) and anti-HBs, anti-HBc IgM and IgG, and hepatitis B e antigen (HBeAg) and anti-HBe. It is transmitted by sexual, parenteral and vertical route. One significant method to diminish the burden of this disease is timely diagnosis of acute, chronic and occult cases of HBV. First step of HBV diagnosis is achieved by using serological markers for detecting antigens and antibodies. In order to verify first step of diagnosis, to quantify viral load and to identify genotypes, quantitative or qualitative molecular tests are used. In this article, the serological and molecular tests for diagnosis of HBV infection will be reviewed.
UR - http://www.scopus.com/inward/record.url?scp=85006219664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006219664&partnerID=8YFLogxK
U2 - 10.21037/atm.2016.09.11
DO - 10.21037/atm.2016.09.11
M3 - Review article
AN - SCOPUS:85006219664
VL - 4
JO - Annals of Translational Medicine
JF - Annals of Translational Medicine
SN - 2305-5839
IS - 18
M1 - 338
ER -