Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

Ki Tae Suk, Dong Joon Kim, Chang Hoon Kim, Seung Ha Park, Jae Youn Cheong, Sung Won Cho, Jong Young Choi, Kwang Hyub Han, Ho Taik Sung, So Hyung Hong, Dae Yong Kim, Jai Hoon Yoon, Yeon Soo Kim, Gwang Ho Baik, Jin Bong Kim

Research output: Contribution to journalArticle

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Abstract

Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.

Original languageEnglish
Pages (from-to)1075-1080
Number of pages6
JournalClinical Biochemistry
Volume45
Issue number13-14
DOIs
Publication statusPublished - 2012 Sep 1

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Haptoglobins
Hepatic Veins
Matrix Metalloproteinase 2
Biomarkers
Hyaluronic Acid
Chronic Hepatitis
Procollagen
Veins
Fibrosis
Apolipoprotein A-I
Liver
Logistic Models
Peptides
Tissue Inhibitor of Metalloproteinase-1
Biopsy
Pressure gradient
Venous Pressure
ROC Curve
Liver Cirrhosis

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Suk, Ki Tae ; Kim, Dong Joon ; Kim, Chang Hoon ; Park, Seung Ha ; Cheong, Jae Youn ; Cho, Sung Won ; Choi, Jong Young ; Han, Kwang Hyub ; Sung, Ho Taik ; Hong, So Hyung ; Kim, Dae Yong ; Yoon, Jai Hoon ; Kim, Yeon Soo ; Baik, Gwang Ho ; Kim, Jin Bong. / Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis. In: Clinical Biochemistry. 2012 ; Vol. 45, No. 13-14. pp. 1075-1080.
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title = "Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis",
abstract = "Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.",
author = "Suk, {Ki Tae} and Kim, {Dong Joon} and Kim, {Chang Hoon} and Park, {Seung Ha} and Cheong, {Jae Youn} and Cho, {Sung Won} and Choi, {Jong Young} and Han, {Kwang Hyub} and Sung, {Ho Taik} and Hong, {So Hyung} and Kim, {Dae Yong} and Yoon, {Jai Hoon} and Kim, {Yeon Soo} and Baik, {Gwang Ho} and Kim, {Jin Bong}",
year = "2012",
month = "9",
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Suk, KT, Kim, DJ, Kim, CH, Park, SH, Cheong, JY, Cho, SW, Choi, JY, Han, KH, Sung, HT, Hong, SH, Kim, DY, Yoon, JH, Kim, YS, Baik, GH & Kim, JB 2012, 'Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis', Clinical Biochemistry, vol. 45, no. 13-14, pp. 1075-1080. https://doi.org/10.1016/j.clinbiochem.2012.04.031

Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis. / Suk, Ki Tae; Kim, Dong Joon; Kim, Chang Hoon; Park, Seung Ha; Cheong, Jae Youn; Cho, Sung Won; Choi, Jong Young; Han, Kwang Hyub; Sung, Ho Taik; Hong, So Hyung; Kim, Dae Yong; Yoon, Jai Hoon; Kim, Yeon Soo; Baik, Gwang Ho; Kim, Jin Bong.

In: Clinical Biochemistry, Vol. 45, No. 13-14, 01.09.2012, p. 1075-1080.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

AU - Suk, Ki Tae

AU - Kim, Dong Joon

AU - Kim, Chang Hoon

AU - Park, Seung Ha

AU - Cheong, Jae Youn

AU - Cho, Sung Won

AU - Choi, Jong Young

AU - Han, Kwang Hyub

AU - Sung, Ho Taik

AU - Hong, So Hyung

AU - Kim, Dae Yong

AU - Yoon, Jai Hoon

AU - Kim, Yeon Soo

AU - Baik, Gwang Ho

AU - Kim, Jin Bong

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.

AB - Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.

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DO - 10.1016/j.clinbiochem.2012.04.031

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AN - SCOPUS:84866024116

VL - 45

SP - 1075

EP - 1080

JO - Clinical Biochemistry

JF - Clinical Biochemistry

SN - 0009-9120

IS - 13-14

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