Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis

Ki Tae Suk, Dong Joon Kim, Chang Hoon Kim, Seung Ha Park, Jae Youn Cheong, Sung Won Cho, Jong Young Choi, Kwang Hyub Han, Ho Taik Sung, So Hyung Hong, Dae Yong Kim, Jai Hoon Yoon, Yeon Soo Kim, Gwang Ho Baik, Jin Bong Kim

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6 Citations (Scopus)

Abstract

Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.

Original languageEnglish
Pages (from-to)1075-1080
Number of pages6
JournalClinical Biochemistry
Volume45
Issue number13-14
DOIs
Publication statusPublished - 2012 Sep 1

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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    Suk, K. T., Kim, D. J., Kim, C. H., Park, S. H., Cheong, J. Y., Cho, S. W., Choi, J. Y., Han, K. H., Sung, H. T., Hong, S. H., Kim, D. Y., Yoon, J. H., Kim, Y. S., Baik, G. H., & Kim, J. B. (2012). Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis. Clinical Biochemistry, 45(13-14), 1075-1080. https://doi.org/10.1016/j.clinbiochem.2012.04.031