TY - JOUR
T1 - Diagnostic accuracy of biomarkers measured in the hepatic vein and peripheral vein in the prediction of advanced fibrosis in patients with chronic viral hepatitis
AU - Suk, Ki Tae
AU - Kim, Dong Joon
AU - Kim, Chang Hoon
AU - Park, Seung Ha
AU - Cheong, Jae Youn
AU - Cho, Sung Won
AU - Choi, Jong Young
AU - Han, Kwang Hyub
AU - Sung, Ho Taik
AU - Hong, So Hyung
AU - Kim, Dae Yong
AU - Yoon, Jai Hoon
AU - Kim, Yeon Soo
AU - Baik, Gwang Ho
AU - Kim, Jin Bong
N1 - Funding Information:
This research was partly supported by a grant from the Ministry of Health and Welfare, Republic of Korea (no. A050021 ) and also by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2010–0021482 ).
PY - 2012/9
Y1 - 2012/9
N2 - Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.
AB - Objectives: The accuracies of biomarkers checked in the hepatic vein (HV) and peripheral vein (PV) were compared in the prediction of advanced fibrosis (AF) of liver. Methods: Patients with chronic viral hepatitis (n = 101) who underwent hepatic venous pressure gradient, liver biopsy, and paired HV-PV samples (6 biomarkers: hyaluronic acid [HA], haptoglobin, matrix metalloproteinase-2 [MMP2], tissue inhibitor of metalloproteinases-1 [TIMP1], procollagen III N-terminal peptide [PIIINP], and apolipoprotein-A1 [Apo-A1]) were enrolled. Results: Differences were displayed between the HV and PV in the predictive logit-models for predicting AF (- 3.13 + 0.017 × MMP2. - 0.019 × haptoglobin and - 0.270 + 0.007 × HA. - 0.018 × haptoglobin, respectively). In the area under the receiver operating characteristic curves, PIIINP (0.74/0.68, p= 0.03), MMP2 (0.72/0.63, p= 0.04), HA (0.79/0.76, p= 0.94), Apo-A1 (0.56/0.48, p= 0.73), and predictive logit-model (0.81/0.78, p= 0.68) showed higher diagnostic value in the HV sample. Conclusions: While most biomarkers were correlated better with hepatic fibrosis in HV than in PV, individually and in predictive logit-models, they were inadequate to determine the degree of advanced fibrosis.
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U2 - 10.1016/j.clinbiochem.2012.04.031
DO - 10.1016/j.clinbiochem.2012.04.031
M3 - Article
C2 - 22579966
AN - SCOPUS:84866024116
VL - 45
SP - 1075
EP - 1080
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 13-14
ER -
