Diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy of ground-glass opacity pulmonary lesions

Jin Hur, Hye Jeong Lee, Ji Eun Nam, Young Jin Kim, Tae Hoon Kim, Kyu Ok Choe, Byoung Wook Choi

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE. The purpose of this study was to evaluate the diagnostic performance of CT fluoroscopy-guided percutaneous needle aspiration biopsy of ground-glass opacity (GGO) pulmonary lesions. MATERIALS AND METHODS. Twenty-eight patients with GGO lesions who underwent CT fluoroscopy-guided needle aspiration biopsy were enrolled in this study. GGO lesions were divided into three groups according to their size: group 1, lesions ≤ 10 mm (n = 10); group 2, lesions 11-20 mm (n = 10); and group 3, lesions > 20 mm (n = 8). Sensitivity, specificity, and diagnostic accuracy were calculated on the basis of 28 needle aspiration biopsy results and were compared among the three groups using Fisher's exact test. Diagnostic accuracy was also compared according to length of needle path (< 5 cm vs 5-9 cm vs > 9 cm) and GGO component (50-90% vs > 90%). Each case was reviewed for complications, which included pneumothorax, thoracostomy tube insertion, and hemoptysis. RESULTS. There were 17 (61%) malignant and 11 (39%) benign lesions. Three (10%) biopsy results were nondiagnostic, all of which were confirmed as benign. The sensitivity, specificity, and accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO were 67%, 100%, and 80% in group 1; 71%, 100%, and 80% in group 2; and 75%, 100%, and 88% in group 3. The diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO was not significantly different among the three groups (p > 0.05). The diagnostic accuracy was not significantly different according to the length of the needle path (p > 0.05). However, diagnostic accuracy was significantly more accurate in mixed GGO lesions than in pure GGO lesions (p = 0.046). Five patients (18%) developed a pneumothorax, two of whom (7%) required placement of a thoracostomy tube. Mild hemoptysis occurred in three patients (11%). CONCLUSION. CT fluoroscopy-guided needle aspiration biopsy is a useful diagnostic technique for GGO pulmonary lesions and has an acceptable complication rate, even for small and deeply located lesions. The diagnostic accuracy is influenced by the GGO component.

Original languageEnglish
Pages (from-to)629-634
Number of pages6
JournalAmerican Journal of Roentgenology
Volume192
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

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Fluoroscopy
Needle Biopsy
Glass
Lung
Thoracostomy
Hemoptysis
Pneumothorax
Needles
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Hur, Jin ; Lee, Hye Jeong ; Nam, Ji Eun ; Kim, Young Jin ; Kim, Tae Hoon ; Choe, Kyu Ok ; Choi, Byoung Wook. / Diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy of ground-glass opacity pulmonary lesions. In: American Journal of Roentgenology. 2009 ; Vol. 192, No. 3. pp. 629-634.
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title = "Diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy of ground-glass opacity pulmonary lesions",
abstract = "OBJECTIVE. The purpose of this study was to evaluate the diagnostic performance of CT fluoroscopy-guided percutaneous needle aspiration biopsy of ground-glass opacity (GGO) pulmonary lesions. MATERIALS AND METHODS. Twenty-eight patients with GGO lesions who underwent CT fluoroscopy-guided needle aspiration biopsy were enrolled in this study. GGO lesions were divided into three groups according to their size: group 1, lesions ≤ 10 mm (n = 10); group 2, lesions 11-20 mm (n = 10); and group 3, lesions > 20 mm (n = 8). Sensitivity, specificity, and diagnostic accuracy were calculated on the basis of 28 needle aspiration biopsy results and were compared among the three groups using Fisher's exact test. Diagnostic accuracy was also compared according to length of needle path (< 5 cm vs 5-9 cm vs > 9 cm) and GGO component (50-90{\%} vs > 90{\%}). Each case was reviewed for complications, which included pneumothorax, thoracostomy tube insertion, and hemoptysis. RESULTS. There were 17 (61{\%}) malignant and 11 (39{\%}) benign lesions. Three (10{\%}) biopsy results were nondiagnostic, all of which were confirmed as benign. The sensitivity, specificity, and accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO were 67{\%}, 100{\%}, and 80{\%} in group 1; 71{\%}, 100{\%}, and 80{\%} in group 2; and 75{\%}, 100{\%}, and 88{\%} in group 3. The diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO was not significantly different among the three groups (p > 0.05). The diagnostic accuracy was not significantly different according to the length of the needle path (p > 0.05). However, diagnostic accuracy was significantly more accurate in mixed GGO lesions than in pure GGO lesions (p = 0.046). Five patients (18{\%}) developed a pneumothorax, two of whom (7{\%}) required placement of a thoracostomy tube. Mild hemoptysis occurred in three patients (11{\%}). CONCLUSION. CT fluoroscopy-guided needle aspiration biopsy is a useful diagnostic technique for GGO pulmonary lesions and has an acceptable complication rate, even for small and deeply located lesions. The diagnostic accuracy is influenced by the GGO component.",
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Diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy of ground-glass opacity pulmonary lesions. / Hur, Jin; Lee, Hye Jeong; Nam, Ji Eun; Kim, Young Jin; Kim, Tae Hoon; Choe, Kyu Ok; Choi, Byoung Wook.

In: American Journal of Roentgenology, Vol. 192, No. 3, 01.03.2009, p. 629-634.

Research output: Contribution to journalArticle

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T1 - Diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy of ground-glass opacity pulmonary lesions

AU - Hur, Jin

AU - Lee, Hye Jeong

AU - Nam, Ji Eun

AU - Kim, Young Jin

AU - Kim, Tae Hoon

AU - Choe, Kyu Ok

AU - Choi, Byoung Wook

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N2 - OBJECTIVE. The purpose of this study was to evaluate the diagnostic performance of CT fluoroscopy-guided percutaneous needle aspiration biopsy of ground-glass opacity (GGO) pulmonary lesions. MATERIALS AND METHODS. Twenty-eight patients with GGO lesions who underwent CT fluoroscopy-guided needle aspiration biopsy were enrolled in this study. GGO lesions were divided into three groups according to their size: group 1, lesions ≤ 10 mm (n = 10); group 2, lesions 11-20 mm (n = 10); and group 3, lesions > 20 mm (n = 8). Sensitivity, specificity, and diagnostic accuracy were calculated on the basis of 28 needle aspiration biopsy results and were compared among the three groups using Fisher's exact test. Diagnostic accuracy was also compared according to length of needle path (< 5 cm vs 5-9 cm vs > 9 cm) and GGO component (50-90% vs > 90%). Each case was reviewed for complications, which included pneumothorax, thoracostomy tube insertion, and hemoptysis. RESULTS. There were 17 (61%) malignant and 11 (39%) benign lesions. Three (10%) biopsy results were nondiagnostic, all of which were confirmed as benign. The sensitivity, specificity, and accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO were 67%, 100%, and 80% in group 1; 71%, 100%, and 80% in group 2; and 75%, 100%, and 88% in group 3. The diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO was not significantly different among the three groups (p > 0.05). The diagnostic accuracy was not significantly different according to the length of the needle path (p > 0.05). However, diagnostic accuracy was significantly more accurate in mixed GGO lesions than in pure GGO lesions (p = 0.046). Five patients (18%) developed a pneumothorax, two of whom (7%) required placement of a thoracostomy tube. Mild hemoptysis occurred in three patients (11%). CONCLUSION. CT fluoroscopy-guided needle aspiration biopsy is a useful diagnostic technique for GGO pulmonary lesions and has an acceptable complication rate, even for small and deeply located lesions. The diagnostic accuracy is influenced by the GGO component.

AB - OBJECTIVE. The purpose of this study was to evaluate the diagnostic performance of CT fluoroscopy-guided percutaneous needle aspiration biopsy of ground-glass opacity (GGO) pulmonary lesions. MATERIALS AND METHODS. Twenty-eight patients with GGO lesions who underwent CT fluoroscopy-guided needle aspiration biopsy were enrolled in this study. GGO lesions were divided into three groups according to their size: group 1, lesions ≤ 10 mm (n = 10); group 2, lesions 11-20 mm (n = 10); and group 3, lesions > 20 mm (n = 8). Sensitivity, specificity, and diagnostic accuracy were calculated on the basis of 28 needle aspiration biopsy results and were compared among the three groups using Fisher's exact test. Diagnostic accuracy was also compared according to length of needle path (< 5 cm vs 5-9 cm vs > 9 cm) and GGO component (50-90% vs > 90%). Each case was reviewed for complications, which included pneumothorax, thoracostomy tube insertion, and hemoptysis. RESULTS. There were 17 (61%) malignant and 11 (39%) benign lesions. Three (10%) biopsy results were nondiagnostic, all of which were confirmed as benign. The sensitivity, specificity, and accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO were 67%, 100%, and 80% in group 1; 71%, 100%, and 80% in group 2; and 75%, 100%, and 88% in group 3. The diagnostic accuracy of CT fluoroscopy-guided needle aspiration biopsy for diagnosing GGO was not significantly different among the three groups (p > 0.05). The diagnostic accuracy was not significantly different according to the length of the needle path (p > 0.05). However, diagnostic accuracy was significantly more accurate in mixed GGO lesions than in pure GGO lesions (p = 0.046). Five patients (18%) developed a pneumothorax, two of whom (7%) required placement of a thoracostomy tube. Mild hemoptysis occurred in three patients (11%). CONCLUSION. CT fluoroscopy-guided needle aspiration biopsy is a useful diagnostic technique for GGO pulmonary lesions and has an acceptable complication rate, even for small and deeply located lesions. The diagnostic accuracy is influenced by the GGO component.

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