Diagnostic Approaches for Salivary Gland Tumors with Secretory and Microcystic Features

Ha Young Woo, Eun Chang Choi, SunOch Yoon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Secretory carcinoma (SC) of the salivary gland is a new entity that shares the unique morphologic features and cytogenetic characteristics of the ETV6-NTRK3 fusion gene with its breast counterpart. Before identification of SC of the salivary gland, it was most frequently diagnosed as acinic cell carcinoma (AciCC). We retrospectively reviewed our own database of salivary gland tumors harboring microcystic and papillary architecture and/or secretory features that were originally diagnosed as AciCC. We selected nine cases of AciCC showing diffuse S-100 expression on immunohistochemistry (IHC). A recently diagnosed case of SC was included in the study as a reference sample. We performed IHC of S-100 and mammaglobin and ETV6 gene fluorescence in situ hybridization (FISH) in all cases. Seven cases were positive for both S-100 and mammaglobin, while five of the seven (71.4%) demonstrated ETV6 gene translocation by FISH. In the cases which did not co-express either S-100 or mammaglobin on IHC, ETV6 gene rearrangement was not shown on FISH. In conclusion, if a salivary gland tumor has morphologic features of SC with co-expression of S-100 and mammaglobin, ETV6 FISH can be performed to confirm the diagnosis of SC of the salivary gland.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalHead and Neck Pathology
Volume12
Issue number2
DOIs
Publication statusPublished - 2018 Jun 1

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Glandular and Epithelial Neoplasms
Acinar Cell Carcinoma
Fluorescence In Situ Hybridization
Carcinoma
Salivary Glands
Immunohistochemistry
Gene Rearrangement
Gene Fusion
Cytogenetics
Genes
Breast
Databases

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

Cite this

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title = "Diagnostic Approaches for Salivary Gland Tumors with Secretory and Microcystic Features",
abstract = "Secretory carcinoma (SC) of the salivary gland is a new entity that shares the unique morphologic features and cytogenetic characteristics of the ETV6-NTRK3 fusion gene with its breast counterpart. Before identification of SC of the salivary gland, it was most frequently diagnosed as acinic cell carcinoma (AciCC). We retrospectively reviewed our own database of salivary gland tumors harboring microcystic and papillary architecture and/or secretory features that were originally diagnosed as AciCC. We selected nine cases of AciCC showing diffuse S-100 expression on immunohistochemistry (IHC). A recently diagnosed case of SC was included in the study as a reference sample. We performed IHC of S-100 and mammaglobin and ETV6 gene fluorescence in situ hybridization (FISH) in all cases. Seven cases were positive for both S-100 and mammaglobin, while five of the seven (71.4{\%}) demonstrated ETV6 gene translocation by FISH. In the cases which did not co-express either S-100 or mammaglobin on IHC, ETV6 gene rearrangement was not shown on FISH. In conclusion, if a salivary gland tumor has morphologic features of SC with co-expression of S-100 and mammaglobin, ETV6 FISH can be performed to confirm the diagnosis of SC of the salivary gland.",
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Diagnostic Approaches for Salivary Gland Tumors with Secretory and Microcystic Features. / Woo, Ha Young; Choi, Eun Chang; Yoon, SunOch.

In: Head and Neck Pathology, Vol. 12, No. 2, 01.06.2018, p. 237-243.

Research output: Contribution to journalArticle

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