Diagnostic performance of %[-2]proPSA and prostate health index for prostate cancer: Prospective, multi-institutional study

Hongzoo Park, Sang Wook Lee, Geehyun Song, Tae Wook Kang, Jae Hung Jung, Hyun Chul Chung, Sung Jin Kim, Chang Hoo Park, Jong Yeon Park, Tae Young Shin, In Bum Suh, Jeong Hyun Kim

Research output: Contribution to journalArticle

Abstract

Background: We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men. Methods: A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses. Results: Overall, PCa was detected in 125 (50.8%) subjects. In men with tPSA 3.5-10 ng/mL, the detection rate of PCa was 39.4% (61/155). In this group, PHI and %p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and %fPSA; area under the curve for tPSA, %fPSA, %p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7. Conclusion: This study demonstrates the superior clinical performance of %p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The %p2PSA and PHI appear to improve detection of PCa and provide prognostic information.

Original languageEnglish
Article numbere94
JournalJournal of Korean medical science
Volume33
Issue number11
DOIs
Publication statusPublished - 2018 Mar 12

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Prostate
Prostatic Neoplasms
Prostate-Specific Antigen
Health
Neoplasm Grading
ROC Curve
Multicenter Studies
Area Under Curve
Observational Studies
Logistic Models
Regression Analysis
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Park, Hongzoo ; Lee, Sang Wook ; Song, Geehyun ; Kang, Tae Wook ; Jung, Jae Hung ; Chung, Hyun Chul ; Kim, Sung Jin ; Park, Chang Hoo ; Park, Jong Yeon ; Shin, Tae Young ; Suh, In Bum ; Kim, Jeong Hyun. / Diagnostic performance of %[-2]proPSA and prostate health index for prostate cancer : Prospective, multi-institutional study. In: Journal of Korean medical science. 2018 ; Vol. 33, No. 11.
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title = "Diagnostic performance of {\%}[-2]proPSA and prostate health index for prostate cancer: Prospective, multi-institutional study",
abstract = "Background: We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men. Methods: A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio ({\%}fPSA), p2PSA, {\%}p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses. Results: Overall, PCa was detected in 125 (50.8{\%}) subjects. In men with tPSA 3.5-10 ng/mL, the detection rate of PCa was 39.4{\%} (61/155). In this group, PHI and {\%}p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and {\%}fPSA; area under the curve for tPSA, {\%}fPSA, {\%}p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7. Conclusion: This study demonstrates the superior clinical performance of {\%}p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The {\%}p2PSA and PHI appear to improve detection of PCa and provide prognostic information.",
author = "Hongzoo Park and Lee, {Sang Wook} and Geehyun Song and Kang, {Tae Wook} and Jung, {Jae Hung} and Chung, {Hyun Chul} and Kim, {Sung Jin} and Park, {Chang Hoo} and Park, {Jong Yeon} and Shin, {Tae Young} and Suh, {In Bum} and Kim, {Jeong Hyun}",
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Diagnostic performance of %[-2]proPSA and prostate health index for prostate cancer : Prospective, multi-institutional study. / Park, Hongzoo; Lee, Sang Wook; Song, Geehyun; Kang, Tae Wook; Jung, Jae Hung; Chung, Hyun Chul; Kim, Sung Jin; Park, Chang Hoo; Park, Jong Yeon; Shin, Tae Young; Suh, In Bum; Kim, Jeong Hyun.

In: Journal of Korean medical science, Vol. 33, No. 11, e94, 12.03.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Diagnostic performance of %[-2]proPSA and prostate health index for prostate cancer

T2 - Prospective, multi-institutional study

AU - Park, Hongzoo

AU - Lee, Sang Wook

AU - Song, Geehyun

AU - Kang, Tae Wook

AU - Jung, Jae Hung

AU - Chung, Hyun Chul

AU - Kim, Sung Jin

AU - Park, Chang Hoo

AU - Park, Jong Yeon

AU - Shin, Tae Young

AU - Suh, In Bum

AU - Kim, Jeong Hyun

PY - 2018/3/12

Y1 - 2018/3/12

N2 - Background: We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men. Methods: A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses. Results: Overall, PCa was detected in 125 (50.8%) subjects. In men with tPSA 3.5-10 ng/mL, the detection rate of PCa was 39.4% (61/155). In this group, PHI and %p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and %fPSA; area under the curve for tPSA, %fPSA, %p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7. Conclusion: This study demonstrates the superior clinical performance of %p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The %p2PSA and PHI appear to improve detection of PCa and provide prognostic information.

AB - Background: We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting the presence and aggressiveness of prostate cancer (PCa) in Korean men. Methods: A total of 246 men with total prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first prostate biopsy were included in this prospective, multicenter, observational study. Diagnostic accuracy of tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, and the Beckman Coulter prostate health index (PHI) was assessed by receiver operating characteristic curve analyses and logistic regression analyses. Results: Overall, PCa was detected in 125 (50.8%) subjects. In men with tPSA 3.5-10 ng/mL, the detection rate of PCa was 39.4% (61/155). In this group, PHI and %p2PSA were the most accurate predictors of PCa and significantly outperformed tPSA and %fPSA; area under the curve for tPSA, %fPSA, %p2PSA, and PHI was 0.56, 0.69, 0.74, and 0.76, respectively. PHI was also the strongest predictor of PCa with Gleason score ≥ 7. Conclusion: This study demonstrates the superior clinical performance of %p2PSA and PHI in predicting the presence and aggressiveness of PCa in Korean men. The %p2PSA and PHI appear to improve detection of PCa and provide prognostic information.

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