Diagnostic performances of HE4 and CA125 for the detection of ovarian cancer from patients with various gynecologic and non-gynecologic diseases

Yongjung Park, Jong Han Lee, Duck Jin Hong, Eun Young Lee, Hyonsuk Kim

Research output: Contribution to journalArticle

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Abstract

Objectives: We compared diagnostic performance of CA125 and HE4 in various gynecologic and non-gynecologic diseases. Design and methods: Sera from 176 patients with various diseases were collected, and CA125 and HE4 levels were compared. ROC curves were constructed to estimate the diagnostic performance. Results: Levels of both markers were elevated in ovarian cancer. CA125 was also high in benign gynecologic diseases, but HE4 was not. CA125 levels of pregnant women were higher than those of control group, and HE4 was increased in chronic renal diseases. The sensitivity for discriminating ovarian cancer from healthy or benign conditions was 44.8% for HE4 and 55.2% for CA125 at 95% specificity. The ROC-AUC values for HE4 and CA125 were 0.85 and 0.87 respectively. ConclusionsHE4 demonstrated comparable diagnostic performances to CA125, though each marker had its own strengths and weaknesses. Combining CA125 and HE4 might be more advantageous than either one alone.

Original languageEnglish
Pages (from-to)884-888
Number of pages5
JournalClinical Biochemistry
Volume44
Issue number10-11
DOIs
Publication statusPublished - 2011 Jul 1

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Ovarian Neoplasms
Female Genital Diseases
Chronic Renal Insufficiency
ROC Curve
Area Under Curve
Pregnant Women
Control Groups
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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abstract = "Objectives: We compared diagnostic performance of CA125 and HE4 in various gynecologic and non-gynecologic diseases. Design and methods: Sera from 176 patients with various diseases were collected, and CA125 and HE4 levels were compared. ROC curves were constructed to estimate the diagnostic performance. Results: Levels of both markers were elevated in ovarian cancer. CA125 was also high in benign gynecologic diseases, but HE4 was not. CA125 levels of pregnant women were higher than those of control group, and HE4 was increased in chronic renal diseases. The sensitivity for discriminating ovarian cancer from healthy or benign conditions was 44.8{\%} for HE4 and 55.2{\%} for CA125 at 95{\%} specificity. The ROC-AUC values for HE4 and CA125 were 0.85 and 0.87 respectively. ConclusionsHE4 demonstrated comparable diagnostic performances to CA125, though each marker had its own strengths and weaknesses. Combining CA125 and HE4 might be more advantageous than either one alone.",
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Diagnostic performances of HE4 and CA125 for the detection of ovarian cancer from patients with various gynecologic and non-gynecologic diseases. / Park, Yongjung; Lee, Jong Han; Hong, Duck Jin; Lee, Eun Young; Kim, Hyonsuk.

In: Clinical Biochemistry, Vol. 44, No. 10-11, 01.07.2011, p. 884-888.

Research output: Contribution to journalArticle

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AU - Lee, Jong Han

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AU - Kim, Hyonsuk

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AB - Objectives: We compared diagnostic performance of CA125 and HE4 in various gynecologic and non-gynecologic diseases. Design and methods: Sera from 176 patients with various diseases were collected, and CA125 and HE4 levels were compared. ROC curves were constructed to estimate the diagnostic performance. Results: Levels of both markers were elevated in ovarian cancer. CA125 was also high in benign gynecologic diseases, but HE4 was not. CA125 levels of pregnant women were higher than those of control group, and HE4 was increased in chronic renal diseases. The sensitivity for discriminating ovarian cancer from healthy or benign conditions was 44.8% for HE4 and 55.2% for CA125 at 95% specificity. The ROC-AUC values for HE4 and CA125 were 0.85 and 0.87 respectively. ConclusionsHE4 demonstrated comparable diagnostic performances to CA125, though each marker had its own strengths and weaknesses. Combining CA125 and HE4 might be more advantageous than either one alone.

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