TY - JOUR
T1 - Diagnostic performances of HE4 and CA125 for the detection of ovarian cancer from patients with various gynecologic and non-gynecologic diseases
AU - Park, Yongjung
AU - Lee, Jong Han
AU - Hong, Duck Jin
AU - Lee, Eun Young
AU - Kim, Hyon Suk
PY - 2011/7
Y1 - 2011/7
N2 - Objectives: We compared diagnostic performance of CA125 and HE4 in various gynecologic and non-gynecologic diseases. Design and methods: Sera from 176 patients with various diseases were collected, and CA125 and HE4 levels were compared. ROC curves were constructed to estimate the diagnostic performance. Results: Levels of both markers were elevated in ovarian cancer. CA125 was also high in benign gynecologic diseases, but HE4 was not. CA125 levels of pregnant women were higher than those of control group, and HE4 was increased in chronic renal diseases. The sensitivity for discriminating ovarian cancer from healthy or benign conditions was 44.8% for HE4 and 55.2% for CA125 at 95% specificity. The ROC-AUC values for HE4 and CA125 were 0.85 and 0.87 respectively. ConclusionsHE4 demonstrated comparable diagnostic performances to CA125, though each marker had its own strengths and weaknesses. Combining CA125 and HE4 might be more advantageous than either one alone.
AB - Objectives: We compared diagnostic performance of CA125 and HE4 in various gynecologic and non-gynecologic diseases. Design and methods: Sera from 176 patients with various diseases were collected, and CA125 and HE4 levels were compared. ROC curves were constructed to estimate the diagnostic performance. Results: Levels of both markers were elevated in ovarian cancer. CA125 was also high in benign gynecologic diseases, but HE4 was not. CA125 levels of pregnant women were higher than those of control group, and HE4 was increased in chronic renal diseases. The sensitivity for discriminating ovarian cancer from healthy or benign conditions was 44.8% for HE4 and 55.2% for CA125 at 95% specificity. The ROC-AUC values for HE4 and CA125 were 0.85 and 0.87 respectively. ConclusionsHE4 demonstrated comparable diagnostic performances to CA125, though each marker had its own strengths and weaknesses. Combining CA125 and HE4 might be more advantageous than either one alone.
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U2 - 10.1016/j.clinbiochem.2011.04.011
DO - 10.1016/j.clinbiochem.2011.04.011
M3 - Article
C2 - 21549107
AN - SCOPUS:79958817864
SN - 0009-9120
VL - 44
SP - 884
EP - 888
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 10-11
ER -
