Diagnostic thyroidectomy may be preferable in patients with suspicious ultrasonography features after cytopathology diagnosis of AUS/FLUS in the bethesda system

Yong Sang Lee, Hyeung Kyoo Kim, Hojin Chang, Seok Mo Kim, Bup Woo Kim, Hang-Seok Chang, Cheong Soo Park

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Atypia/follicular lesion of undetermined significance (AUS/ FLUS) is a new category in the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) for which repeat fine-needle aspiration cytology (FNAC) is recommended. The aim of this study was to identify specific ultrasonography and clinical predictors of malignancy in a subset of thyroid nodules associated with cytology diagnoses of AUS/ FLUS. Between January 2011 and December 2102, 5440 patients underwent thyroid surgery at our institution. Of these, 213 patients were diagnosed AUS/FLUS at the preoperative cytopathology diagnosis. The frequency of FNAC and ultrasonography images was compared between patients with cancerous and benign tumors based on their final pathology. Of the 213 patients, 158 (74.2%) were diagnosed with thyroid carcinoma in their final pathology reports. In univariate and multivariate analyses, the frequency of FNAC was not significantly correlated with the cancer diagnosis. Hypoechogenicity (odds ratio 2.521, P1/40.007) and microcalcification (odds ratio 3.247, P1/40.005) were statistically correlated with cancer risk. Although AUS/FLUS in cytopathology is recommended for repeating FNAC in BSRTC, we proposed that thyroid nodules with ultrasonography findings that suggest the possibility of cancer should undergo thyroidectomy with diagnostic intent.

Original languageEnglish
Article numbere2183
JournalMedicine (United States)
Volume94
Issue number51
DOIs
Publication statusPublished - 2015 Jan 1

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Thyroidectomy
Cell Biology
Ultrasonography
Fine Needle Biopsy
Thyroid Gland
Thyroid Nodule
Neoplasms
Odds Ratio
Pathology
Calcinosis
Thyroid Neoplasms
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Diagnostic thyroidectomy may be preferable in patients with suspicious ultrasonography features after cytopathology diagnosis of AUS/FLUS in the bethesda system",
abstract = "Atypia/follicular lesion of undetermined significance (AUS/ FLUS) is a new category in the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) for which repeat fine-needle aspiration cytology (FNAC) is recommended. The aim of this study was to identify specific ultrasonography and clinical predictors of malignancy in a subset of thyroid nodules associated with cytology diagnoses of AUS/ FLUS. Between January 2011 and December 2102, 5440 patients underwent thyroid surgery at our institution. Of these, 213 patients were diagnosed AUS/FLUS at the preoperative cytopathology diagnosis. The frequency of FNAC and ultrasonography images was compared between patients with cancerous and benign tumors based on their final pathology. Of the 213 patients, 158 (74.2{\%}) were diagnosed with thyroid carcinoma in their final pathology reports. In univariate and multivariate analyses, the frequency of FNAC was not significantly correlated with the cancer diagnosis. Hypoechogenicity (odds ratio 2.521, P1/40.007) and microcalcification (odds ratio 3.247, P1/40.005) were statistically correlated with cancer risk. Although AUS/FLUS in cytopathology is recommended for repeating FNAC in BSRTC, we proposed that thyroid nodules with ultrasonography findings that suggest the possibility of cancer should undergo thyroidectomy with diagnostic intent.",
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Diagnostic thyroidectomy may be preferable in patients with suspicious ultrasonography features after cytopathology diagnosis of AUS/FLUS in the bethesda system. / Lee, Yong Sang; Kim, Hyeung Kyoo; Chang, Hojin; Kim, Seok Mo; Kim, Bup Woo; Chang, Hang-Seok; Park, Cheong Soo.

In: Medicine (United States), Vol. 94, No. 51, e2183, 01.01.2015.

Research output: Contribution to journalArticle

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AU - Lee, Yong Sang

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AU - Kim, Bup Woo

AU - Chang, Hang-Seok

AU - Park, Cheong Soo

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