Diagnostic value of Cyfra 21-1 measurement in fine-needle aspiration washouts for detection of axillary recurrence in postoperative breast cancer patients

So Yeon Won, Eun Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Min Jung Kim

Research output: Contribution to journalArticle

Abstract

Purpose The objective of this study was to evaluate the diagnostic value and threshold levels of cytokeratin fragment 21-1 (CYFRA 21-1) in fine-needle aspiration (FNA) washouts for detection of lymph node (LN) recurrence in postoperative breast cancer patients. Materials and Methods FNA cytological assessments and CYFRA 21-1 measurement in FNA washouts were performed for 64 axillary LNs suspicious for recurrence in 64 post-operative breast cancer patients. Final diagnosis was made on the basis of FNA cytology and follow-up data over at least 2 years. The concentration of CYFRA 21-1 was compared between recurrent LNs and benign LNs. Diagnostic performance and cut-off value were evaluated using a receiver operating characteristic curve. Results Regardless of the non-diagnostic results, the median concentration of CYFRA 21-1 in recurrent LNs was significantly higher than that in benign LNs (p < 0.001). The optimal diagnostic cut-off value was 1.6 ng/mL. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CYFRA 21-1 for LN recurrence were 90.9%, 100%, 100%, 98.1%, and 98.4%, respectively. Conclusion Measurement of CYFRA 21-1 concentration from ultrasound-guided FNA biopsy aspirates showed excellent diagnostic performance with a cut-off value of 1.6 ng/mL. These results indicate that measurement of CYFRA 21-1 concentration in FNA washouts is useful for the diagnosis of axillary LN recurrence in post-operative breast cancer patients.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalJournal of the Korean Society of Radiology
Volume81
Issue number1
DOIs
Publication statusPublished - 2020 Jan

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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