Diagnostic value of procalcitonin and C-reactive protein in differentiation of pleural effusions

Sangha Kim, Young Park Joo, Sook Park Hyun, Seok Seo Hee, Tae Kim Shin, Whan Kim Chong, Ghil Lee Bu, Jeong Lee Seok, Nyung Lee Shun, Kyu Non Jin, Su Lee Min, Yeon Lee Won, Joong Yong Suk, Chul Shin Kye

Research output: Contribution to journalArticle

Abstract

Background: Malignancies are a common and important causes of exudative pleural effusions. Several tumor markers have been studied because the pleural fluid cytology and pleural biopsy specimens do not provide a diagnosis in a high percentage of malignant effusions. In an attempt to overcome this limitation, procalcitonin and C-reactive protein (CRP) in pleural effusions and serum, which are known to be inflammation markers, were measured to determine if they can differentiate an exudate from trasndate as well as the diverse causes of exudative pleural effusion. Methods: 178 consecutive patients with pleural effusion (malignant 57, tuberculous 51, parapneumonic 31, empyema 5, miscellaneous benign 7, transudative 27)were studied prospectively. The standard parameters of pleural effusion and measured serum and pleural procalcitonin were examined using in immunoluminometric assay. The level of CRP in serum and pleural fluid was determined by turbidimetric immunoassay. Results: The pleural procalcitonin levels in the exudate were significantly higher than those in the transudate, 0.81±3.09 ng/mL and 0.12±0.12 ng/mL, respectively (p=0.007). The pleural CRP levels were significantly higher in the exudate than the transudate, 2.83±3.31 mg/dL and 0.74±0.67 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the benign effusion were significantly higher than those in the malignant effusion, 1.15±3.82 ng/mL and 0.25±0.92 ng/mL, respectively (p=0.032). The pleural CRP levels were significantly higher in the benign effusion than in the malignant effusion, 3.68±3.78 mg/dL and 1.42±1.54 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the non-tuberculous effusion were significantly higher than those in the tuberculous effusion, 1.16±3.75 ng/mL and 0.13±0.37 ng/mL, respectively (p=0.008). Conclusion: Measuring the level of procalcitonin and CRP in the pleural fluid is helpful for differentiating between transudates and exudates. In addition, it is useful for differentiating between benign and malignant pleural effusions.

Original languageEnglish
Pages (from-to)353-361
Number of pages9
JournalTuberculosis and Respiratory Diseases
Volume63
Issue number4
DOIs
Publication statusPublished - 2007 Jan 1

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Calcitonin
Pleural Effusion
C-Reactive Protein
Exudates and Transudates
Malignant Pleural Effusion
Serum
Empyema
Tumor Biomarkers
Immunoassay
Cell Biology
Inflammation
Biopsy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Kim, Sangha ; Joo, Young Park ; Hyun, Sook Park ; Hee, Seok Seo ; Shin, Tae Kim ; Chong, Whan Kim ; Bu, Ghil Lee ; Seok, Jeong Lee ; Shun, Nyung Lee ; Jin, Kyu Non ; Min, Su Lee ; Won, Yeon Lee ; Suk, Joong Yong ; Kye, Chul Shin. / Diagnostic value of procalcitonin and C-reactive protein in differentiation of pleural effusions. In: Tuberculosis and Respiratory Diseases. 2007 ; Vol. 63, No. 4. pp. 353-361.
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abstract = "Background: Malignancies are a common and important causes of exudative pleural effusions. Several tumor markers have been studied because the pleural fluid cytology and pleural biopsy specimens do not provide a diagnosis in a high percentage of malignant effusions. In an attempt to overcome this limitation, procalcitonin and C-reactive protein (CRP) in pleural effusions and serum, which are known to be inflammation markers, were measured to determine if they can differentiate an exudate from trasndate as well as the diverse causes of exudative pleural effusion. Methods: 178 consecutive patients with pleural effusion (malignant 57, tuberculous 51, parapneumonic 31, empyema 5, miscellaneous benign 7, transudative 27)were studied prospectively. The standard parameters of pleural effusion and measured serum and pleural procalcitonin were examined using in immunoluminometric assay. The level of CRP in serum and pleural fluid was determined by turbidimetric immunoassay. Results: The pleural procalcitonin levels in the exudate were significantly higher than those in the transudate, 0.81±3.09 ng/mL and 0.12±0.12 ng/mL, respectively (p=0.007). The pleural CRP levels were significantly higher in the exudate than the transudate, 2.83±3.31 mg/dL and 0.74±0.67 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the benign effusion were significantly higher than those in the malignant effusion, 1.15±3.82 ng/mL and 0.25±0.92 ng/mL, respectively (p=0.032). The pleural CRP levels were significantly higher in the benign effusion than in the malignant effusion, 3.68±3.78 mg/dL and 1.42±1.54 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the non-tuberculous effusion were significantly higher than those in the tuberculous effusion, 1.16±3.75 ng/mL and 0.13±0.37 ng/mL, respectively (p=0.008). Conclusion: Measuring the level of procalcitonin and CRP in the pleural fluid is helpful for differentiating between transudates and exudates. In addition, it is useful for differentiating between benign and malignant pleural effusions.",
author = "Sangha Kim and Joo, {Young Park} and Hyun, {Sook Park} and Hee, {Seok Seo} and Shin, {Tae Kim} and Chong, {Whan Kim} and Bu, {Ghil Lee} and Seok, {Jeong Lee} and Shun, {Nyung Lee} and Jin, {Kyu Non} and Min, {Su Lee} and Won, {Yeon Lee} and Suk, {Joong Yong} and Kye, {Chul Shin}",
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doi = "10.4046/trd.2007.63.4.353",
language = "English",
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Kim, S, Joo, YP, Hyun, SP, Hee, SS, Shin, TK, Chong, WK, Bu, GL, Seok, JL, Shun, NL, Jin, KN, Min, SL, Won, YL, Suk, JY & Kye, CS 2007, 'Diagnostic value of procalcitonin and C-reactive protein in differentiation of pleural effusions', Tuberculosis and Respiratory Diseases, vol. 63, no. 4, pp. 353-361. https://doi.org/10.4046/trd.2007.63.4.353

Diagnostic value of procalcitonin and C-reactive protein in differentiation of pleural effusions. / Kim, Sangha; Joo, Young Park; Hyun, Sook Park; Hee, Seok Seo; Shin, Tae Kim; Chong, Whan Kim; Bu, Ghil Lee; Seok, Jeong Lee; Shun, Nyung Lee; Jin, Kyu Non; Min, Su Lee; Won, Yeon Lee; Suk, Joong Yong; Kye, Chul Shin.

In: Tuberculosis and Respiratory Diseases, Vol. 63, No. 4, 01.01.2007, p. 353-361.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Diagnostic value of procalcitonin and C-reactive protein in differentiation of pleural effusions

AU - Kim, Sangha

AU - Joo, Young Park

AU - Hyun, Sook Park

AU - Hee, Seok Seo

AU - Shin, Tae Kim

AU - Chong, Whan Kim

AU - Bu, Ghil Lee

AU - Seok, Jeong Lee

AU - Shun, Nyung Lee

AU - Jin, Kyu Non

AU - Min, Su Lee

AU - Won, Yeon Lee

AU - Suk, Joong Yong

AU - Kye, Chul Shin

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background: Malignancies are a common and important causes of exudative pleural effusions. Several tumor markers have been studied because the pleural fluid cytology and pleural biopsy specimens do not provide a diagnosis in a high percentage of malignant effusions. In an attempt to overcome this limitation, procalcitonin and C-reactive protein (CRP) in pleural effusions and serum, which are known to be inflammation markers, were measured to determine if they can differentiate an exudate from trasndate as well as the diverse causes of exudative pleural effusion. Methods: 178 consecutive patients with pleural effusion (malignant 57, tuberculous 51, parapneumonic 31, empyema 5, miscellaneous benign 7, transudative 27)were studied prospectively. The standard parameters of pleural effusion and measured serum and pleural procalcitonin were examined using in immunoluminometric assay. The level of CRP in serum and pleural fluid was determined by turbidimetric immunoassay. Results: The pleural procalcitonin levels in the exudate were significantly higher than those in the transudate, 0.81±3.09 ng/mL and 0.12±0.12 ng/mL, respectively (p=0.007). The pleural CRP levels were significantly higher in the exudate than the transudate, 2.83±3.31 mg/dL and 0.74±0.67 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the benign effusion were significantly higher than those in the malignant effusion, 1.15±3.82 ng/mL and 0.25±0.92 ng/mL, respectively (p=0.032). The pleural CRP levels were significantly higher in the benign effusion than in the malignant effusion, 3.68±3.78 mg/dL and 1.42±1.54 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the non-tuberculous effusion were significantly higher than those in the tuberculous effusion, 1.16±3.75 ng/mL and 0.13±0.37 ng/mL, respectively (p=0.008). Conclusion: Measuring the level of procalcitonin and CRP in the pleural fluid is helpful for differentiating between transudates and exudates. In addition, it is useful for differentiating between benign and malignant pleural effusions.

AB - Background: Malignancies are a common and important causes of exudative pleural effusions. Several tumor markers have been studied because the pleural fluid cytology and pleural biopsy specimens do not provide a diagnosis in a high percentage of malignant effusions. In an attempt to overcome this limitation, procalcitonin and C-reactive protein (CRP) in pleural effusions and serum, which are known to be inflammation markers, were measured to determine if they can differentiate an exudate from trasndate as well as the diverse causes of exudative pleural effusion. Methods: 178 consecutive patients with pleural effusion (malignant 57, tuberculous 51, parapneumonic 31, empyema 5, miscellaneous benign 7, transudative 27)were studied prospectively. The standard parameters of pleural effusion and measured serum and pleural procalcitonin were examined using in immunoluminometric assay. The level of CRP in serum and pleural fluid was determined by turbidimetric immunoassay. Results: The pleural procalcitonin levels in the exudate were significantly higher than those in the transudate, 0.81±3.09 ng/mL and 0.12±0.12 ng/mL, respectively (p=0.007). The pleural CRP levels were significantly higher in the exudate than the transudate, 2.83±3.31 mg/dL and 0.74±0.67 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the benign effusion were significantly higher than those in the malignant effusion, 1.15±3.82 ng/mL and 0.25±0.92 ng/mL, respectively (p=0.032). The pleural CRP levels were significantly higher in the benign effusion than in the malignant effusion, 3.68±3.78 mg/dL and 1.42±1.54 mg/dL, respectively (p<0.001). The pleural procalcitonin levels in the non-tuberculous effusion were significantly higher than those in the tuberculous effusion, 1.16±3.75 ng/mL and 0.13±0.37 ng/mL, respectively (p=0.008). Conclusion: Measuring the level of procalcitonin and CRP in the pleural fluid is helpful for differentiating between transudates and exudates. In addition, it is useful for differentiating between benign and malignant pleural effusions.

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