Dibenzocyclooctadiene Lignans from Schisandra chinensis Protect Primary Cultures of Rat Cortical Cells from Glutamate-Induced Toxicity

So Ra Kim, Mi Kyeong Lee, Kyung Ah Koo, Seung Hyun Kim, Sang Hyun Sung, Na Gyong Lee, George J. Markelonis, Tae H. Oh, Jae Ho Yang, Young Choong Kim

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Abstract

A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells. Five dibenzocyclooctadiene lignans (deoxyschisandrin, gomisin N, gomisin A, schisandrin, and wuweizisu C) were isolated from the methanolic extract; their protective effects against glutamate-induced neurotoxicity were then evaluated. Among the five lignans, deoxyschisandrin, gomisin N, and wuweizisu C significantly attenuated glutamate-induced neurotoxicity as measured by 1) an inhibition in the increase of intracellular [Ca2+]; 2) an improvement in the glutathione defense system, the level of glutathione, and the activity of glutathione peroxidase; and 3) an inhibition in the formation of cellular peroxide. These results suggest that dibenzocyclooctadiene lignans from Schisandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxin.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalJournal of Neuroscience Research
Volume76
Issue number3
DOIs
Publication statusPublished - 2004 May 1

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

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    Kim, S. R., Lee, M. K., Koo, K. A., Kim, S. H., Sung, S. H., Lee, N. G., Markelonis, G. J., Oh, T. H., Yang, J. H., & Kim, Y. C. (2004). Dibenzocyclooctadiene Lignans from Schisandra chinensis Protect Primary Cultures of Rat Cortical Cells from Glutamate-Induced Toxicity. Journal of Neuroscience Research, 76(3), 397-405. https://doi.org/10.1002/jnr.20089