Abstract
In this study, we develop an in vivo dielectric imaging technique that measures capacitance using pin-type electrode arrays. Compared to normal tissues, cancer tissues exhibit higher capacitance values, allowing us to image the cancer region and monitor the chemotherapeutic effects of cancer in real-time. A comparison with the histopathological results shows that the in vivo dielectric imaging technique is able to detect small tumors (<3 mm) and tumor-associated changes. In addition, we demonstrate that cancer and inflammation may be distinguished by measuring the capacitance images at different frequencies. In contrast, the positron emission tomography using 2-[18F]-fluoro-2-deoxy-D-glucose was not capable of discriminating between cancer and inflammation.
| Original language | English |
|---|---|
| Article number | 13137 |
| Journal | Scientific reports |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2017 Dec 1 |
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All Science Journal Classification (ASJC) codes
- General
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Dielectric imaging for differentiation between cancer and inflammation in vivo. / Lee, Rimi; Lee, Sun Mi; Kim, Hyung Joon; Kim, Sook Young; Son, Mina; Song, Jun Ho; Lkhamsuren, Khulan; Park, In Ho; Choi, In Hong; Park, Young Nyun; Shin, Jeon Soo; Yoo, Kyung Hwa.
In: Scientific reports, Vol. 7, No. 1, 13137, 01.12.2017.Research output: Contribution to journal › Article
TY - JOUR
T1 - Dielectric imaging for differentiation between cancer and inflammation in vivo
AU - Lee, Rimi
AU - Lee, Sun Mi
AU - Kim, Hyung Joon
AU - Kim, Sook Young
AU - Son, Mina
AU - Song, Jun Ho
AU - Lkhamsuren, Khulan
AU - Park, In Ho
AU - Choi, In Hong
AU - Park, Young Nyun
AU - Shin, Jeon Soo
AU - Yoo, Kyung Hwa
PY - 2017/12/1
Y1 - 2017/12/1
N2 - In this study, we develop an in vivo dielectric imaging technique that measures capacitance using pin-type electrode arrays. Compared to normal tissues, cancer tissues exhibit higher capacitance values, allowing us to image the cancer region and monitor the chemotherapeutic effects of cancer in real-time. A comparison with the histopathological results shows that the in vivo dielectric imaging technique is able to detect small tumors (<3 mm) and tumor-associated changes. In addition, we demonstrate that cancer and inflammation may be distinguished by measuring the capacitance images at different frequencies. In contrast, the positron emission tomography using 2-[18F]-fluoro-2-deoxy-D-glucose was not capable of discriminating between cancer and inflammation.
AB - In this study, we develop an in vivo dielectric imaging technique that measures capacitance using pin-type electrode arrays. Compared to normal tissues, cancer tissues exhibit higher capacitance values, allowing us to image the cancer region and monitor the chemotherapeutic effects of cancer in real-time. A comparison with the histopathological results shows that the in vivo dielectric imaging technique is able to detect small tumors (<3 mm) and tumor-associated changes. In addition, we demonstrate that cancer and inflammation may be distinguished by measuring the capacitance images at different frequencies. In contrast, the positron emission tomography using 2-[18F]-fluoro-2-deoxy-D-glucose was not capable of discriminating between cancer and inflammation.
UR - http://www.scopus.com/inward/record.url?scp=85031668995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031668995&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-13545-3
DO - 10.1038/s41598-017-13545-3
M3 - Article
C2 - 29030581
AN - SCOPUS:85031668995
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 13137
ER -