Dielectric imaging for differentiation between cancer and inflammation in vivo

Rimi Lee, Sun Mi Lee, Hyung Joon Kim, Sook Young Kim, Mina Son, Jun Ho Song, Khulan Lkhamsuren, In Ho Park, In Hong Choi, Young Nyun Park, Jeon Soo Shin, Kyung Hwa Yoo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In this study, we develop an in vivo dielectric imaging technique that measures capacitance using pin-type electrode arrays. Compared to normal tissues, cancer tissues exhibit higher capacitance values, allowing us to image the cancer region and monitor the chemotherapeutic effects of cancer in real-time. A comparison with the histopathological results shows that the in vivo dielectric imaging technique is able to detect small tumors (<3 mm) and tumor-associated changes. In addition, we demonstrate that cancer and inflammation may be distinguished by measuring the capacitance images at different frequencies. In contrast, the positron emission tomography using 2-[18F]-fluoro-2-deoxy-D-glucose was not capable of discriminating between cancer and inflammation.

Original languageEnglish
Article number13137
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

Bibliographical note

Funding Information:
This work was financially supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science (Grant Nos. NRF-2016R1A2B3011980, NRF-2016R1A2B4014999, NRF-2012R1A4A10209061, NRF-2014R1A4A1008625, and 2017R1A2B3006704), and Brain Korea 21 PLUS project for Medical Science.

Publisher Copyright:
© 2017 The Author(s).

All Science Journal Classification (ASJC) codes

  • General

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